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RIPK1 Produits

(Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))
Serine-threonine kinase which transduces inflammatory and cell-death signals (necroptosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necroptosis-inducing complex.

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Catégories RIPK1 en vedette

RIPK1 Anticorps

High quality antibodies with extensive validation data.

RIPK1 Kits ELISA

Reliable ELISA kits for a wide range of species.

RIPK1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

RIPK1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (6)
N° du produit ABIN7441202
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Rat
Application WB, IHC, IP, ICC
Validations
  • (7)
N° du produit ABIN7441205
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC, IP, IF
Validations
  • (6)
N° du produit ABIN6146959
Quantité 100 μL
Fiche technique Fiche technique

RIPK1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
N° du produit ABIN6959056
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6969845
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6969846
Quantité 96 tests
Fiche technique Fiche technique

RIPK1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (2)
  • (1)
N° du produit ABIN1318108
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7124799
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1318110
Quantité 10 μg
Fiche technique Fiche technique

Dernières publications sur nos produits RIPK1

Horiguchi, Yoshida, Hasegawa, Takigami, Ohsako, Kato, Kato: "Isolation and characterization of cluster of differentiation 9-positive ependymal cells as potential adult neural stem/progenitor cells in the third ventricle of adult rats." dans: Cell and tissue research, Vol. 379, Issue 3, pp. 497-509, (2020) (PubMed).

Wu, Fournel, Stadler, Liu, Boullier, Hoyeau, Fléjou, Duchatelle, Djebrani-Oussedik, Agopiantz, Ségal-Bendirdjian, Gompel, Alifano, Melander, Trédaniel, Forgez: "Modulation of lung cancer cell plasticity and heterogeneity with the restoration of cisplatin sensitivity by neurotensin antibody." dans: Cancer letters, Vol. 444, pp. 147-161, (2019) (PubMed).

Bao, Fan, Zhao, Xu, Liu, Chao, Liu, You, Liu, Wang, Ji: "Silencing of A20 Aggravates Neuronal Death and Inflammation After Traumatic Brain Injury: A Potential Trigger of Necroptosis." dans: Frontiers in molecular neuroscience, Vol. 12, pp. 222, (2019) (PubMed).

Du, Ge, Jing, Pan: "Necroptosis in pulmonary macrophages mediates lipopolysaccharide-induced lung inflammatory injury by activating ZBP-1." dans: International immunopharmacology, Vol. 77, pp. 105944, (2019) (PubMed).

Li, Shi, Pan, Zhao, Yan, Li, Lei: "Transcription modulation by CDK9 regulates inflammatory genes and RIPK3-MLKL-mediated necroptosis in periodontitis progression." dans: Scientific reports, Vol. 9, Issue 1, pp. 17369, (2019) (PubMed).

Tsuiji, Inoue, Takeuchi, Furuya, Yamakage, Watanabe, Koike, Hattori, Yamanaka: "TDP-43 accelerates age-dependent degeneration of interneurons." dans: Scientific reports, Vol. 7, Issue 1, pp. 14972, (2018) (PubMed).

Ghardashi Afousi, Gaeini, Rakhshan, Naderi, Darbandi Azar, Aboutaleb: "Targeting necroptotic cell death pathway by high-intensity interval training (HIIT) decreases development of post-ischemic adverse remodelling after myocardial ischemia / reperfusion injury." dans: Journal of cell communication and signaling, (2018) (PubMed).

Zhang, Wang, Zhang, Xiong, Zhang, Tang, Luo, Ma, Peng: "Vascular peroxide 1 promotes ox-LDL-induced programmed necrosis in endothelial cells through a mechanism involving β-catenin signaling." dans: Atherosclerosis, Vol. 274, pp. 128-138, (2018) (PubMed).

Wang, Ma, Hu, Xie, Wu, Zeng, Song: "Bifidobacterial recombinant thymidine kinase-ganciclovir gene therapy system induces FasL and TNFR2 mediated antitumor apoptosis in solid tumors." dans: BMC cancer, Vol. 16, pp. 545, (2017) (PubMed).

Al-Lamki, Lu, Manalo, Wang, Warren, Tolkovsky, Pober, Bradley: "Tubular epithelial cells in renal clear cell carcinoma express high RIPK1/3 and show increased susceptibility to TNF receptor 1-induced necroptosis." dans: Cell death & disease, Vol. 7, Issue 6, pp. e2287, (2016) (PubMed).

Synonymes et noms alternatifs relatifs à RIPK1

receptor interacting serine/threonine kinase 1 (RIPK1), receptor (TNFRSF)-interacting serine-threonine kinase 1 (Ripk1), receptor interacting serine/threonine kinase 1 (Ripk1), receptor interacting serine/threonine kinase 1 L homeolog (ripk1.L), D330015H01Rik, Rinp, RIP, RIP1, Rip1, rip1, ripk1, xrip1, xRIP1beta

Protein level used designations for RIPK1

  • RIP-1
  • cell death protein RIP
  • receptor interacting protein
  • receptor-interacting protein 1
  • receptor-interacting serine/threonine-protein kinase 1
  • serine/threonine-protein kinase RIP
  • receptor (TNFRSF)-interacting serine-threonine kinase 1
  • receptor interacting serine/threonine kinase 1 L homeolog
  • receptor-interacting protein 1 beta
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