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RNF139 Produits

(Ring Finger Protein 139 (RNF139))

Catégories

The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008].

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Catégories RNF139 en vedette

RNF139 Anticorps

High quality antibodies with extensive validation data.

RNF139 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

RNF139 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, IHC (p)
Validations
  • (1)
  • (4)
N° du produit ABIN564887
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Bat, Cow, Dog, Guinea Pig, Human, Mouse, Pig, Rabbit, Rat
Application WB, IHC, IHC (p)
Validations
  • (3)
N° du produit ABIN6749727
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
N° du produit ABIN7151154
Quantité 100 μL
Fiche technique Fiche technique

RNF139 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1318244
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1318242
Quantité 10 μg
Fiche technique Fiche technique

Dernières publications sur nos produits RNF139

Lin, Lan, Chau: "TRC8 suppresses tumorigenesis through targeting heme oxygenase-1 for ubiquitination and degradation." dans: Oncogene, Vol. 32, Issue 18, pp. 2325-34, (2013) (PubMed).

Adams, Simms, Abdelhamed, Dawe, Szymanska, Logan, Wheway, Pitt, Gull, Knowles, Blair, Cross, Sayer, Johnson: "A meckelin-filamin A interaction mediates ciliogenesis." dans: Human molecular genetics, Vol. 21, Issue 6, pp. 1272-86, (2012) (PubMed).

Lee, Brauweiler, Rudolph, Hooper, Drabkin, Gemmill: "The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways." dans: Molecular cancer research : MCR, Vol. 8, Issue 1, pp. 93-106, (2010) (PubMed).

Irisawa, Inoue, Ozawa, Mori, Sato et al.: "The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces ..." dans: The Journal of biological chemistry, Vol. 284, Issue 42, pp. 28995-9004, (2009) (PubMed).

Stagg, Thomas, van den Boomen, Wiertz, Drabkin, Gemmill, Lehner: "The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER." dans: The Journal of cell biology, Vol. 186, Issue 5, pp. 685-92, (2009) (PubMed).

Brauweiler, Lorick, Lee, Tsai, Chan, Weissman, Drabkin, Gemmill: "RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene." dans: Oncogene, Vol. 26, Issue 16, pp. 2263-71, (2007) (PubMed).

Synonymes et noms alternatifs relatifs à RNF139

ring finger protein 139 (RNF139), ring finger protein 139 (Rnf139), ring finger protein 139 (rnf139), ring finger protein 139 S homeolog (rnf139.S), 4930555P18Rik, HRCA1, RCA1, rnf139, TRC8, zgc:175173

Protein level used designations for RNF139

  • E3 ubiquitin-protein ligase RNF139
  • multiple membrane spanning receptor TRC8
  • patched related protein translocated in renal cancer
  • translocation in renal carcinoma on chromosome 8 protein
  • RING finger protein 139
  • ring finger protein 139 S homeolog
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