RRM2B Produits
(Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))
Catégories
This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010].
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Catégories RRM2B en vedette
RRM2B Anticorps
High quality antibodies with extensive validation data.
RRM2B Kits ELISA
Reliable ELISA kits for a wide range of species.
RRM2B Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
RRM2B recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (2)
- (2)
N° du produit
ABIN565482
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, IP
Validations
- (2)
N° du produit
ABIN7168147
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, IP
Validations
- (5)
- (1)
N° du produit
ABIN964915
Quantité
100 μg
Fiche technique
Fiche technique
RRM2B recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6969961
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6951228
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Validations
N° du produit
ABIN1155811
Quantité
96 tests
Fiche technique
Fiche technique
RRM2B recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1318906
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7317292
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3087246
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits RRM2B
: "Ribonucleotide reductase subunit M2B deficiency leads to mitochondrial permeability transition pore opening and is associated with aggressive clinicopathologic manifestations of breast cancer." dans: American journal of translational research, Vol. 10, Issue 11, pp. 3635-3649, (2018) (PubMed).: "p53R2 regulates thioredoxin reductase activity through interaction with TrxR2." dans: Biochemical and biophysical research communications, Vol. 482, Issue 4, pp. 706-712, (2016) (PubMed).
: "Autophagy induction causes a synthetic lethal sensitization to ribonucleotide reductase inhibition in breast cancer cells." dans: Oncotarget, Vol. 7, Issue 2, pp. 1984-99, (2016) (PubMed).
: "RRM2B suppresses activation of the oxidative stress pathway and is up-regulated by p53 during senescence." dans: Scientific reports, Vol. 2, pp. 822, (2013) (PubMed).
: "Ribonucleotide reductase small subunit M2B prognoses better survival in colorectal cancer." dans: Cancer research, Vol. 71, Issue 9, pp. 3202-13, (2011) (PubMed).
: "Ribonucleotide reductase subunit p53R2 regulates mitochondria homeostasis and function in KB and PC-3 cancer cells." dans: Biochemical and biophysical research communications, Vol. 410, Issue 1, pp. 102-7, (2011) (PubMed).
: "Ribonucleotide reductase small subunit p53R2 suppresses MEK-ERK activity by binding to ERK kinase 2." dans: Oncogene, Vol. 28, Issue 21, pp. 2173-84, (2009) (PubMed).
: "Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits." dans: Cancer research, Vol. 63, Issue 5, pp. 980-6, (2003) (PubMed).
: "Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells." dans: The Journal of biological chemistry, Vol. 276, Issue 44, pp. 40647-51, (2001) (PubMed).
: "p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint." dans: Cancer research, Vol. 61, Issue 22, pp. 8256-62, (2001) (PubMed).
Synonymes et noms alternatifs relatifs à RRM2B
ribonucleotide reductase M2 B (TP53 inducible) S homeolog (rrm2b.S), ribonucleotide reductase regulatory TP53 inducible subunit M2B (RRM2B), ribonucleotide reductase M2 B (TP53 inducible) (rrm2b), ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), ribonucleotide reductase regulatory TP53 inducible subunit M2B (Rrm2b), MTDPS8A, MTDPS8B, p53r2, P53R2, p53R2, RRM2BProtein level used designations for RRM2B
- ribonucleotide reductase M2 B (TP53 inducible)
- ribonucleoside-diphosphate reductase subunit M2 B
- TP53-inducible ribonucleotide reductase M2 B
- p53-inducible ribonucleotide reductase small subunit 2 homolog
- p53-inducible ribonucleotide reductase small subunit 2 short form beta
- p53-inducible ribonucleotide reductase small subunit 2-like protein
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