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RSPO1 Produits

(R-Spondin 1 (RSPO1))
This gene is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. [provided by RefSeq, Jul 2008].

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Catégories RSPO1 en vedette

RSPO1 Anticorps

High quality antibodies with extensive validation data.

RSPO1 Kits ELISA

Reliable ELISA kits for a wide range of species.

RSPO1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

RSPO1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (8)
N° du produit ABIN7430144
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (6)
N° du produit ABIN7430147
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Rat
Application WB, IHC, IP, ICC
Validations
  • (8)
N° du produit ABIN7437200
Quantité 100 μL
Fiche technique Fiche technique

RSPO1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
N° du produit ABIN6959020
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6975875
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6999503
Quantité 96 tests
Fiche technique Fiche technique

RSPO1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source CHO Cells
Validations
  • (3)
N° du produit ABIN7275537
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (2)
N° du produit ABIN7275538
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
N° du produit ABIN2181686
Quantité 50 μg
Fiche technique Fiche technique

Dernières publications sur nos produits RSPO1

Igarashi, Miura, Williams, Jaksch, Kadowaki, Yamauchi, Guarente: "NAD+ supplementation rejuvenates aged gut adult stem cells." dans: Aging cell, Vol. 18, Issue 3, pp. e12935, (2020) (PubMed).

Mihaylova, Cheng, Cao, Tripathi, Mana, Bauer-Rowe, Abu-Remaileh, Clavain, Erdemir, Lewis, Freinkman, Dickey, La Spada, Huang, Bell, Deshpande, Carmeliet, Katajisto, Sabatini, Yilmaz: "Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging." dans: Cell stem cell, Vol. 22, Issue 5, pp. 769-778.e4, (2019) (PubMed).

Park, Choi, Kim, Cheong, Jeong: "AhR activation by 6-formylindolo[3,2-b]carbazole and 2,3,7,8-tetrachlorodibenzo-p-dioxin inhibit the development of mouse intestinal epithelial cells." dans: Environmental toxicology and pharmacology, Vol. 43, pp. 44-53, (2017) (PubMed).

Choi, Chang, Cho, Kang, Shin, Song, Lee et al.: "The association of radiographic progression with serum R-spondin 1 (RSPO1) levels or Dickkopf-1 (DKK1)/RSPO1 ratios in rheumatoid arthritis patients: clinical evidence for reciprocal inhibition ..." dans: Scandinavian journal of rheumatology, Vol. 43, Issue 6, pp. 453-61, (2014) (PubMed).

Du, Luo, Li, Tan, Han, Lu, Li, Qian, Zhang, Zhao, Liu: "Lgr4/Gpr48 negatively regulates TLR2/4-associated pattern recognition and innate immunity by targeting CD14 expression." dans: The Journal of biological chemistry, Vol. 288, Issue 21, pp. 15131-41, (2013) (PubMed).

Moad, Pioszak: "Reconstitution of R-spondin:LGR4:ZNRF3 adult stem cell growth factor signaling complexes with recombinant proteins produced in Escherichia coli." dans: Biochemistry, Vol. 52, Issue 41, pp. 7295-304, (2013) (PubMed).

Das, Png, Oancea, Hasnain, Lourie, Proctor, Eri, Sheng, Crane, Florin, McGuckin: "Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins." dans: The Journal of experimental medicine, Vol. 210, Issue 6, pp. 1201-16, (2013) (PubMed).

Tomaselli, Megiorni, De Bernardo, Felici, Marrocco, Maggiulli, Grammatico, Remotti, Saccucci, Valentini, Mazzilli, Majore, Grammatico: "Syndromic true hermaphroditism due to an R-spondin1 (RSPO1) homozygous mutation." dans: Human mutation, Vol. 29, Issue 2, pp. 220-6, (2008) (PubMed).

Parma, Radi, Vidal, Chaboissier, Dellambra, Valentini, Guerra, Schedl, Camerino: "R-spondin1 is essential in sex determination, skin differentiation and malignancy." dans: Nature genetics, Vol. 38, Issue 11, pp. 1304-9, (2006) (PubMed).

Takahashi, Sato, Kurashima, Yamamoto, Kurokawa, Yuki, Takemura, Uematsu, Lai, Otsu, Matsuno, Osawa, Mizushima, Nishimura, Hayashi, Yamaguchi, Kiyono: "A Refined Culture System for Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Organoids." dans: Stem cell reports, Vol. 10, Issue 1, pp. 314-328 (PubMed).

Synonymes et noms alternatifs relatifs à RSPO1

R-spondin 1 (Rspo1), R-spondin 1 (RSPO1), R-spondin 1 (LOC100049655), R-spondin 1 (rspo1), CRISTIN3, R-spondin, RGD1565558, RSPO, Rspondin, wu:fj81e05, zgc:92153

Protein level used designations for RSPO1

  • R-spondin-1
  • R-spondin homolog
  • roof plate-specific spondin-1
  • R-spondin1
  • cristin-3
  • cysteine-rich and single thrombospondin domain-containing protein 3
  • mCristin-3
  • thrombospondin type 1 domain containing gene Rspondin
  • ovarian R-spondin member 1
  • Roof plate-specific spondin-1
  • cb1071
  • fj81e05
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