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SAV1 Produits

(Salvador Homolog 1 (SAV1))

Catégories

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. [provided by RefSeq, Aug 2012].

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Catégories SAV1 en vedette

SAV1 Anticorps

High quality antibodies with extensive validation data.

SAV1 Kits ELISA

Reliable ELISA kits for a wide range of species.

SAV1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

SAV1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, IF, IP
Validations
  • (6)
  • (6)
N° du produit ABIN566210
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (5)
N° du produit ABIN7166095
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC, IF, IP
Validations
  • (5)
N° du produit ABIN7166096
Quantité 100 μL
Fiche technique Fiche technique

SAV1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method
Validations
N° du produit ABIN1152411
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method
Validations
N° du produit ABIN1152412
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method
Validations
N° du produit ABIN1152413
Quantité 96 tests
Fiche technique Fiche technique

SAV1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1319183
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3095196
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3136732
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits SAV1

Leach, Heallen, Zhang, Rahmani, Morikawa, Hill, Segura, Willerson, Martin: "Hippo pathway deficiency reverses systolic heart failure after infarction." dans: Nature, Vol. 550, Issue 7675, pp. 260-264, (2018) (PubMed).

Kai, Tsukamoto, Hijiya, Tokunaga, Nakada, Uchida, Daa, Iha, Takahashi, Nomura, Sato, Mimata, Ikawa, Seto, Matsuura, Moriyama: "Kidney-specific knockout of Sav1 in the mouse promotes hyperproliferation of renal tubular epithelium through suppression of the Hippo pathway." dans: The Journal of pathology, Vol. 239, Issue 1, pp. 97-108, (2016) (PubMed).

Schütte, Bisht, Heukamp, Kebschull, Florin, Haarmann, Hoffmann, Bendas, Buettner, Brossart, Feldmann: "Hippo signaling mediates proliferation, invasiveness, and metastatic potential of clear cell renal cell carcinoma." dans: Translational oncology, Vol. 7, Issue 2, pp. 309-21, (2014) (PubMed).

Chan, Lim, Guo, Tan, Leung, Hong: "Actin-binding and cell proliferation activities of angiomotin family members are regulated by Hippo pathway-mediated phosphorylation." dans: The Journal of biological chemistry, Vol. 288, Issue 52, pp. 37296-307, (2013) (PubMed).

Park, Kim, Won, Jeon, Oh, Lee, Kim, Lee: "Mammalian ste20-like kinase and SAV1 promote 3T3-L1 adipocyte differentiation by activation of PPAR?." dans: PLoS ONE, Vol. 7, Issue 1, pp. e30983, (2012) (PubMed).

Li, Luo, Li, Wang, Xiao, Tao, Gong, Hu: "Screening of binding proteins that interact with human Salvador 1 in a human fetal liver cDNA library by the yeast two-hybrid system." dans: Molecular biology reports, Vol. 39, Issue 8, pp. 8225-30, (2012) (PubMed).

Murakami, Mizuno, Taniguchi, Fujii, Ishiguro, Fukui, Akatsuka, Horio, Hida, Kondo, Toyokuni, Osada, Sekido: "LATS2 is a tumor suppressor gene of malignant mesothelioma." dans: Cancer research, Vol. 71, Issue 3, pp. 873-83, (2011) (PubMed).

Donninger, Allen, Henson, Pogue, Williams, Gordon, Kassler, Dunwell, Latif, Clark: "Salvador protein is a tumor suppressor effector of RASSF1A with hippo pathway-independent functions." dans: The Journal of biological chemistry, Vol. 286, Issue 21, pp. 18483-91, (2011) (PubMed).

Mardin, Lange, Baxter, Hardy, Scholz, Fry, Schiebel: "Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction." dans: Nature cell biology, Vol. 12, Issue 12, pp. 1166-76, (2010) (PubMed).

Yoo, Soung, Lee, Park, Kim, Nam, Han, Kim, Lee, Lee: "Mutational analysis of salvador gene in human carcinomas." dans: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 111, Issue 6, pp. 595-8, (2003) (PubMed).

Synonymes et noms alternatifs relatifs à SAV1

salvador family WW domain containing protein 1 (SAV1), salvador family WW domain containing 1 (Sav1), salvador family WW domain containing protein 1 (Sav1), 1700040G09Rik, Salv, SAV, Sav, WW45, Wwp3, WWP4, Wwp4

Protein level used designations for SAV1

  • 1700040G09Rik
  • 45 kDa WW domain protein
  • WW domain-containing
  • hWW45
  • protein salvador homolog 1
  • WW domain-containing protein 3
  • WW domain-containing protein 4
  • Salvador homolog 1 protein
  • rWW45
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