SAV1 Produits
(Salvador Homolog 1 (SAV1))
Catégories
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. [provided by RefSeq, Aug 2012].
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Catégories SAV1 en vedette
SAV1 Anticorps
High quality antibodies with extensive validation data.
SAV1 Kits ELISA
Reliable ELISA kits for a wide range of species.
SAV1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
SAV1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IF, IP
Validations
- (6)
- (6)
N° du produit
ABIN566210
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (5)
N° du produit
ABIN7166095
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, IF, IP
Validations
- (5)
N° du produit
ABIN7166096
Quantité
100 μL
Fiche technique
Fiche technique
SAV1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Validations
N° du produit
ABIN1152411
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Validations
N° du produit
ABIN1152412
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Validations
N° du produit
ABIN1152413
Quantité
96 tests
Fiche technique
Fiche technique
SAV1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1319183
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3095196
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3136732
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits SAV1
: "Hippo pathway deficiency reverses systolic heart failure after infarction." dans: Nature, Vol. 550, Issue 7675, pp. 260-264, (2018) (PubMed).: "Kidney-specific knockout of Sav1 in the mouse promotes hyperproliferation of renal tubular epithelium through suppression of the Hippo pathway." dans: The Journal of pathology, Vol. 239, Issue 1, pp. 97-108, (2016) (PubMed).
: "Hippo signaling mediates proliferation, invasiveness, and metastatic potential of clear cell renal cell carcinoma." dans: Translational oncology, Vol. 7, Issue 2, pp. 309-21, (2014) (PubMed).
: "Actin-binding and cell proliferation activities of angiomotin family members are regulated by Hippo pathway-mediated phosphorylation." dans: The Journal of biological chemistry, Vol. 288, Issue 52, pp. 37296-307, (2013) (PubMed).
: "Mammalian ste20-like kinase and SAV1 promote 3T3-L1 adipocyte differentiation by activation of PPAR?." dans: PLoS ONE, Vol. 7, Issue 1, pp. e30983, (2012) (PubMed).
: "Screening of binding proteins that interact with human Salvador 1 in a human fetal liver cDNA library by the yeast two-hybrid system." dans: Molecular biology reports, Vol. 39, Issue 8, pp. 8225-30, (2012) (PubMed).
: "LATS2 is a tumor suppressor gene of malignant mesothelioma." dans: Cancer research, Vol. 71, Issue 3, pp. 873-83, (2011) (PubMed).
: "Salvador protein is a tumor suppressor effector of RASSF1A with hippo pathway-independent functions." dans: The Journal of biological chemistry, Vol. 286, Issue 21, pp. 18483-91, (2011) (PubMed).
: "Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction." dans: Nature cell biology, Vol. 12, Issue 12, pp. 1166-76, (2010) (PubMed).
: "Mutational analysis of salvador gene in human carcinomas." dans: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 111, Issue 6, pp. 595-8, (2003) (PubMed).
Synonymes et noms alternatifs relatifs à SAV1
salvador family WW domain containing protein 1 (SAV1), salvador family WW domain containing 1 (Sav1), salvador family WW domain containing protein 1 (Sav1), 1700040G09Rik, Salv, SAV, Sav, WW45, Wwp3, WWP4, Wwp4Protein level used designations for SAV1
- 1700040G09Rik
- 45 kDa WW domain protein
- WW domain-containing
- hWW45
- protein salvador homolog 1
- WW domain-containing protein 3
- WW domain-containing protein 4
- Salvador homolog 1 protein
- rWW45
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