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Senataxin Produits

(Senataxin (SETX))

Catégories

This gene encodes a protein named for its homology to the Sen1p protein of fungi which has RNA helicase activity encoded by a domain at the C-terminal end of the protein. The protein encoded by this gene contains a DNA/RNA helicase domain at its C-terminal end which suggests that it may be involved in both DNA and RNA processing. Mutations in this gene have been associated with ataxia-ocular apraxia-2 (AOA2) and an autosomal dominant form of juvenile amyotrophic lateral sclerosis (ALS4). [provided by RefSeq, Jul 2008].

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Catégories Senataxin en vedette

Senataxin Anticorps

High quality antibodies with extensive validation data.

Senataxin Kits ELISA

Reliable ELISA kits for a wide range of species.

Senataxin recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, IF
Validations
  • (5)
N° du produit ABIN565001
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application ELISA, IHC
Validations
  • (1)
N° du produit ABIN7164533
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Mouse
Application WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p), ICC
Validations
  • (1)
N° du produit ABIN1385872
Quantité 100 μL
Fiche technique Fiche technique

Senataxin recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method
Validations
N° du produit ABIN1149655
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method
Validations
N° du produit ABIN1149656
Quantité 96 tests
Fiche technique Fiche technique

Senataxin recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1319693
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source HEK-293T Cells
Validations
  • (1)
N° du produit ABIN2731631
Quantité 20 μg
Fiche technique Fiche technique

Dernières publications sur nos produits Senataxin

Makharashvili, Arora, Yin, Fu, Wen, Lee, Kao, Leung, Miller, Paull: "Sae2/CtIP prevents R-loop accumulation in eukaryotic cells." dans: eLife, Vol. 7, (2019) (PubMed).

Cristini, Ricci, Britton, Salimbeni, Huang, Marinello, Calsou, Pommier, Favre, Capranico, Gromak, Sordet: "Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks." dans: Cell reports, Vol. 28, Issue 12, pp. 3167-3181.e6, (2019) (PubMed).

Cohen, Puget, Lin, Clouaire, Aguirrebengoa, Rocher, Pasero, Canitrot, Legube: "Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations." dans: Nature communications, Vol. 9, Issue 1, pp. 533, (2018) (PubMed).

Andrews, McCartney, Errington, DAndrea, Macara: "A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links." dans: Nature communications, Vol. 9, Issue 1, pp. 2592, (2018) (PubMed).

Choudhury, Vs, Mushtaq, Kumar: "Altered translational repression of an RNA-binding protein, Elav by AOA2-causative Senataxin mutation." dans: Synapse (New York, N.Y.), Vol. 71, Issue 5, (2017) (PubMed).

Nguyen, Yadav, Giri, Saez, Graubert, Zou: "Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1." dans: Molecular cell, Vol. 65, Issue 5, pp. 832-847.e4, (2017) (PubMed).

Zhao, Gish, Braunschweig, Li, Ni, Schmitges, Zhong, Liu, Li, Moffat, Vedadi, Min, Pawson, Blencowe, Greenblatt: "SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination." dans: Nature, Vol. 529, Issue 7584, pp. 48-53, (2016) (PubMed).

Richard, Feng, Manley: "A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage." dans: Genes & development, Vol. 27, Issue 20, pp. 2227-32, (2013) (PubMed).

Synonymes et noms alternatifs relatifs à Senataxin

senataxin (SETX), senataxin (setx), senataxin (Setx), A130090N03, A930037J23Rik, ALS4, Als4, AOA2, AW060766, bA479K20.2, mKIAA0625, RGD1565575, SCAR1, Sen1, SETX, wu:fj92h09

Protein level used designations for Senataxin

  • senataxin
  • amyotrophic lateral sclerosis 4
  • probable helicase senataxin-like
  • SEN1 homolog
  • amyotrophic lateral sclerosis 4 protein
  • probable helicase senataxin
  • amyotrophic lateral sclerosis 4 homolog
  • amyotrophic lateral sclerosis 4 protein homolog
  • DEAxQ-box helicase
  • tRNA splicing endonuclease regulator 1
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