SET Domain Containing (Lysine Methyltransferase) 8 Produits
(SET Domain Containing (Lysine Methyltransferase) 8 (SETD8))
Catégories
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes (By similarity).
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Catégories SET Domain Containing (Lysine Methyltransferase) 8 en vedette
SET Domain Containing (Lysine Methyltransferase) 8 Anticorps
High quality antibodies with extensive validation data.
SET Domain Containing (Lysine Methyltransferase) 8 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
SET Domain Containing (Lysine Methyltransferase) 8 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
ELISA, ICC, FACS
Validations
- (5)
N° du produit
ABIN7193329
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IF, IHC (p)
Validations
- (1)
- (3)
N° du produit
ABIN387779
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Application
WB, ELISA, IHC, IF
Validations
- (5)
N° du produit
ABIN3032551
Quantité
0.4 mL
Fiche technique
Fiche technique
SET Domain Containing (Lysine Methyltransferase) 8 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6951049
Quantité
96 tests
Fiche technique
Fiche technique
SET Domain Containing (Lysine Methyltransferase) 8 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7125068
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3093468
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3134954
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits SET Domain Containing (Lysine Methyltransferase) 8
: "Product specificity and mechanism of protein lysine methyltransferases: insights from the histone lysine methyltransferase SET8." dans: Biochemistry, Vol. 47, Issue 25, pp. 6671-7, (2010) (PubMed).: "Epidermal stem cells are defined by global histone modifications that are altered by Myc-induced differentiation." dans: PLoS ONE, Vol. 2, Issue 8, pp. e763, (2010) (PubMed).
: "An miR-502-binding site single-nucleotide polymorphism in the 3'-untranslated region of the SET8 gene is associated with early age of breast cancer onset." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 19, pp. 6292-300, (2009) (PubMed).
: "Catalytic function of the PR-Set7 histone H4 lysine 20 monomethyltransferase is essential for mitotic entry and genomic stability." dans: The Journal of biological chemistry, Vol. 283, Issue 28, pp. 19478-88, (2008) (PubMed).
: "PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin." dans: Molecular cell, Vol. 9, Issue 6, pp. 1201-13, (2002) (PubMed).
: "Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase." dans: Current biology : CB, Vol. 12, Issue 13, pp. 1086-99, (2002) (PubMed).
Synonymes et noms alternatifs relatifs à SET Domain Containing (Lysine Methyltransferase) 8
lysine methyltransferase 5A (KMT5A), lysine methyltransferase 5A (Kmt5a), lysine methyltransferase 5Ab (kmt5ab), lysine methyltransferase 5A S homeolog (kmt5a.S), lysine methyltransferase 5Aa (kmt5aa), 2410195B05Rik, AA617402, AW536475, KMT5A, kmt5a, kmt5a-a, PR-Set7, PR-SET7, Pr-set7, RGD1305893, SET07, SET8, set8a, Setd8, setd8, setd8-a, setd8a, setd8b, wu:fc23f12, wu:fj33f02, zgc:153719, zgc:171649Protein level used designations for SET Domain Containing (Lysine Methyltransferase) 8
- H4-K20-HMTase SETD8
- H4-K20-specific histone methyltransferase
- H4K20-specific histone methyltransferase splice variant Set8b
- N-lysine methyltransferase SETD8
- PR/SET domain containing protein 8
- PR/SET domain-containing protein 07
- PR/SET07
- SET domain-containing protein 8
- histone-lysine N-methyltransferase SETD8
- lysine N-methyltransferase 5A
- PR-Set7
- SET domain-containing 8
- SET domain containing (lysine methyltransferase) 8b
- SET domain containing 8b
- N-lysine methyltransferase KMT5A
- SET domain containing (lysine methyltransferase) 8
- histone methyltransferase Pr-set7/Set8
- lysine (K)-specific methyltransferase 5A
- Histone-lysine N-methyltransferase KMT5A-A
- Lysine-specific methylase 5A-A
- N-lysine methyltransferase KMT5A-A
- N-lysine methyltransferase SETD8-A
- SET domain-containing protein 8-A
- histone-lysine N-methyltransferase KMT5A-A
- histone-lysine N-methyltransferase SETD8-A
- lysine (K)-specific methyltransferase 5A S homeolog
- lysine-specific methylase 5A-A
- PR/SET domain containing protein 8a
- SET domain containing (lysine methyltransferase) 8a
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