Souris anti-Humain IgM (Chain mu), (Fab Region) Anticorps

N° du produit ABIN371468

Détail du produit

Antigène: IgM

Épitope: Chain mu, Fab Region

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Application: Immunofluorescence (IF), Enzyme Immunoassay (EIA), Functional Studies (Func)

Purification: Purified

Clone: UHB

Isotype: IgG3

Information d'application

Indications d'application: Human B Cell Stimulation: < / = 10 μg/mL.

Other applications not tested.
Otimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.25 mg/mL

Buffer: Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added.

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -28 °C for longer.

Détail du antigène

Antigène: IgM

Abstract: IgM Produits

Classe de substances: Antibody

Sujet: IgM normally constitutes about 10 % of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and is largely confined to plasma due to it's large size. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. Due to it's high valency IgM is more efficient than other isotypes is binding antigens with repeating epitopes (virus particles and red blood cells) and is more efficient than IgG in activiating the complement pathway. The gene for the mu constant region contains four domains separated by short intervening sequences. IgM measurement yields information about the body's immediate resistance and response to infection as well as information related to specific diseases. Decreased levels are associated with immune deficiency states, hereditary deficiencies, and myeloma. Increased levels can be associated with Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease.Synonyms: Human Immunoglobulin M