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SGOL2 Produits

(Shugoshin-Like 2 (SGOL2))

Catégories

Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments.

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Catégories SGOL2 en vedette

SGOL2 Anticorps

High quality antibodies with extensive validation data.

SGOL2 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB
Validations
  • (5)
  • (1)
N° du produit ABIN1881800
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human
Application ELISA, IHC
Validations
N° du produit ABIN7188086
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application ELISA, IHC
Validations
N° du produit ABIN6287322
Quantité 50 μL
Fiche technique Fiche technique

SGOL2 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3095378
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3135963
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits SGOL2

Gantchev, Martínez Villarreal, Xie, Lefrançois, Gunn, Netchiporouk, Sasseville, Litvinov: "The Ectopic Expression of Meiosis Regulatory Genes in Cutaneous T-Cell Lymphomas (CTCL)." dans: Frontiers in oncology, Vol. 9, pp. 429, (2019) (PubMed).

Deeraksa, Pan, Sha, Liu, Eissa, Lin, Yu-Lee: "Plk1 is upregulated in androgen-insensitive prostate cancer cells and its inhibition leads to necroptosis." dans: Oncogene, Vol. 32, Issue 24, pp. 2973-83, (2013) (PubMed).

Lindsey, Byrnes, Eller, Rosa, Dabas, Escandon, Grichnik: "Potential role of meiosis proteins in melanoma chromosomal instability." dans: Journal of skin cancer, Vol. 2013, pp. 190109, (2013) (PubMed).

Tanno, Kitajima, Honda, Ando, Ishiguro, Watanabe: "Phosphorylation of mammalian Sgo2 by Aurora B recruits PP2A and MCAK to centromeres." dans: Genes & development, Vol. 24, Issue 19, pp. 2169-79, (2010) (PubMed).

Ross, Katzov-Eckert, Dubé, Brooks, Rassekh, Barhdadi, Feroz-Zada, Visscher, Brown, Rieder, Rogers, Phillips, Carleton, Hayden: "Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy." dans: Nature genetics, Vol. 41, Issue 12, pp. 1345-9, (2009) (PubMed).

Lee, Kitajima, Tanno, Yoshida, Morita, Miyano, Miyake, Watanabe: "Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cells." dans: Nature cell biology, Vol. 10, Issue 1, pp. 42-52, (2008) (PubMed).

Huang, Feng, Famulski, Rattner, Liu, Kao, Muschel, Chan, Yen: "Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments." dans: The Journal of cell biology, Vol. 177, Issue 3, pp. 413-24, (2007) (PubMed).

Kitajima, Sakuno, Ishiguro, Iemura, Natsume, Kawashima, Watanabe: "Shugoshin collaborates with protein phosphatase 2A to protect cohesin." dans: Nature, Vol. 441, Issue 7089, pp. 46-52, (2006) (PubMed).

Synonymes et noms alternatifs relatifs à SGOL2

shugoshin 2 (SGO2), shugoshin 2A (Sgo2a), 1110007N04Rik, 4932411A20Rik, 5730576N04Rik, AU018846, AV008062, D1Ertd8e, SGO2, TRIPIN, Tripin

Protein level used designations for SGOL2

  • shugoshin-2
  • shugoshin-like 2
  • sgo2
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