SH2D1A Produits
(SH2 Domain Containing 1A (SH2D1A))
Catégories
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Catégories SH2D1A en vedette
SH2D1A Anticorps
High quality antibodies with extensive validation data.
SH2D1A Kits ELISA
Reliable ELISA kits for a wide range of species.
SH2D1A Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
SH2D1A recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA
Validations
- (5)
- (4)
N° du produit
ABIN561703
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IF
Validations
- (4)
N° du produit
ABIN3021536
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (2)
N° du produit
ABIN7169449
Quantité
100 μg
Fiche technique
Fiche technique
SH2D1A recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN4884511
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6386237
Quantité
96 tests
Fiche technique
Fiche technique
SH2D1A recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7125076
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1319861
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7319330
Quantité
50 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits SH2D1A
: "Decreased SAP Expression in T Cells from Patients with Systemic Lupus Erythematosus Contributes to Early Signaling Abnormalities and Reduced IL-2 Production." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 196, Issue 12, pp. 4915-24, (2016) (PubMed).: "Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance." dans: The Journal of allergy and clinical immunology, Vol. 133, Issue 4, pp. 1149-61, (2014) (PubMed).
: "Diagnosing XLP1 in patients with hemophagocytic lymphohistiocytosis." dans: The Journal of allergy and clinical immunology, Vol. 134, Issue 6, pp. 1381-1387.e7, (2014) (PubMed).
: "Expansion of somatically reverted memory CD8+ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus." dans: The Journal of experimental medicine, Vol. 209, Issue 5, pp. 913-24, (2012) (PubMed).
: "Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP." dans: PLoS biology, Vol. 9, Issue 11, pp. e1001187, (2011) (PubMed).
: "Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12." dans: Immunology and cell biology, Vol. 87, Issue 8, pp. 590-600, (2009) (PubMed).
: "Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency." dans: The Journal of clinical investigation, Vol. 119, Issue 10, pp. 2976-89, (2009) (PubMed).
: "The proapoptotic function of SAP provides a clue to the clinical picture of X-linked lymphoproliferative disease." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 29, pp. 11966-71, (2009) (PubMed).
: "SAP binds to CD22 and regulates B cell inhibitory signaling and calcium flux." dans: Cellular signalling, Vol. 21, Issue 4, pp. 540-50, (2009) (PubMed).
: "Customised molecular diagnosis of primary immune deficiency disorders in New Zealand: an efficient strategy for a small developed country." dans: The New Zealand medical journal, Vol. 122, Issue 1304, pp. 46-53, (2009) (PubMed).
Synonymes et noms alternatifs relatifs à SH2D1A
SH2 domain containing 1A (SH2D1A), SH2 domain containing 1A (Sh2d1a), DSHP, EBVS, Gm686, IMD5, LYP, MTCP1, RGD1562408, SAP, SAP/SH2D1A, SH2D1A, XLP, XLPDProtein level used designations for SH2D1A
- Duncan disease SH2-protein
- SH2 domain-containing protein 1A
- SLAM associated protein/SH2 domain protein 1A
- SLAM-associated protein
- T cell signal transduction molecule SAP
- T-cell signal transduction molecule SAP
- signaling lymphocyte activation molecule-associated protein
- signaling lymphocytic activation molecule-associated protein
- SH2 domain protein 1A
- SH2 domain protein 1A, Duncan's disease (lymphoproliferative syndrome)
- Signaling lymphocytic activation molecule-associated protein
- Duncan disease homolog
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