SHP1 Produits
(Protein-tyrosine Phosphatase 1C (PTPN6))
Catégories
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008].
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Catégories SHP1 en vedette
SHP1 Anticorps
High quality antibodies with extensive validation data.
SHP1 Kits ELISA
Reliable ELISA kits for a wide range of species.
SHP1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
SHP1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC (p), IP, IHC (fro)
Validations
- (6)
N° du produit
ABIN2855500
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, IF, FACS, StM
Validations
- (7)
N° du produit
ABIN6939660
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IF, IHC (p)
Validations
- (2)
- (4)
N° du produit
ABIN1882123
Quantité
400 μL
Fiche technique
Fiche technique
SHP1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6958967
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Qualitative Cell ELISA
Validations
N° du produit
ABIN5691915
Quantité
2 x 96 tests
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
N° du produit
ABIN5691914
Quantité
2 x 96 tests
Fiche technique
Fiche technique
SHP1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7124693
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1316851
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN666674
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits SHP1
: "Membrane nanoclusters of FcγRI segregate from inhibitory SIRPα upon activation of human macrophages." dans: The Journal of cell biology, Vol. 216, Issue 4, pp. 1123-1141, (2017) (PubMed).: "SHP-1 Acts as a Key Regulator of Alloresponses by Modulating LFA-1-Mediated Adhesion in Primary Murine T Cells." dans: Molecular and cellular biology, Vol. 36, Issue 24, pp. 3113-3127, (2016) (PubMed).
: "SC-2001 overcomes STAT3-mediated sorafenib resistance through RFX-1/SHP-1 activation in hepatocellular carcinoma." dans: Neoplasia (New York, N.Y.), Vol. 16, Issue 7, pp. 595-605, (2014) (PubMed).
: "Constitutive activation of STAT3 in Sézary syndrome is independent of SHP-1." dans: Leukemia, Vol. 26, Issue 2, pp. 323-31, (2012) (PubMed).
: "Downregulation of platelet responsiveness upon contact with LDL by the protein-tyrosine phosphatases SHP-1 and SHP-2." dans: Arteriosclerosis, thrombosis, and vascular biology, Vol. 29, Issue 3, pp. 372-9, (2009) (PubMed).
: "Tyrosine phosphatase SHP-1 in oxidative stress and development of allergic airway inflammation." dans: American journal of respiratory cell and molecular biology, Vol. 39, Issue 4, pp. 412-9, (2008) (PubMed).
: "Activation of Cdk2 stimulates proteasome-dependent truncation of tyrosine phosphatase SHP-1 in human proliferating intestinal epithelial cells." dans: The Journal of biological chemistry, Vol. 283, Issue 37, pp. 25544-56, (2008) (PubMed).
: "SHP1 tyrosine phosphatase negatively regulates NPM-ALK tyrosine kinase signaling." dans: Blood, Vol. 107, Issue 10, pp. 4130-8, (2006) (PubMed).
: "The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis." dans: Nature medicine, Vol. 12, Issue 5, pp. 549-56, (2006) (PubMed).
: "Regulation of SHP-1 tyrosine phosphatase in human platelets by serine phosphorylation at its C terminus." dans: The Journal of biological chemistry, Vol. 279, Issue 39, pp. 40475-83, (2004) (PubMed).
Synonymes et noms alternatifs relatifs à SHP1
protein tyrosine phosphatase, non-receptor type 6 (PTPN6), protein tyrosine phosphatase, non-receptor type 6 (Ptpn6), protein tyrosine phosphatase, non-receptor type 6 (ptpn6), protein tyrosine phosphatase, non-receptor type 6 L homeolog (ptpn6.L), DRPLA, fj22f05, HCPH, Hcph, HPTP1C, me, motheaten, PTP-1C, Ptp1C, Ptph6, ptpn6, SH-PTP1, SHP-1, Shp-1, SHP-1L, SHP1, wu:fj22f05, zgc:55501Protein level used designations for SHP1
- hematopoietic cell phosphatase
- hematopoietic cell protein-tyrosine phosphatase
- protein-tyrosine phosphatase 1C
- protein-tyrosine phosphatase SHP-1
- tyrosine-protein phosphatase non-receptor type 6
- dentatorubro-pallidoluysian atrophy protein
- non-receptor type protein tyrosine phosphatase SHP1
- 70Z-SHP
- PTP-1C
- PTPTY-42
- SH-PTP1
- hemopoietic cell phosphatase
- SH2 phosphatase 1
- protein tyrosine phosphatase, non-receptor type 6 L homeolog
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