SIGLEC12 Produits
(Sialic Acid Binding Ig-Like Lectin 12 (SIGLEC12))
Catégories
Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
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Catégories SIGLEC12 en vedette
SIGLEC12 Anticorps
High quality antibodies with extensive validation data.
SIGLEC12 Kits ELISA
Reliable ELISA kits for a wide range of species.
SIGLEC12 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
SIGLEC12 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
N° du produit
ABIN529939
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (2)
N° du produit
ABIN7437041
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
IHC, ELISA
Validations
- (1)
N° du produit
ABIN7169557
Quantité
100 μL
Fiche technique
Fiche technique
SIGLEC12 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN511596
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rabbit
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN775684
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Guinea Pig
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN777649
Quantité
96 tests
Fiche technique
Fiche technique
SIGLEC12 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1319989
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1319987
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1319985
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits SIGLEC12
: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." dans: Genome research, Vol. 13, Issue 10, pp. 2265-70, (2003) (PubMed).: "Identification and characterization of S2V, a novel putative siglec that contains two V set Ig-like domains and recruits protein-tyrosine phosphatases SHPs." dans: The Journal of biological chemistry, Vol. 276, Issue 26, pp. 23816-24, (2001) (PubMed).
: "A second uniquely human mutation affecting sialic acid biology." dans: The Journal of biological chemistry, Vol. 276, Issue 43, pp. 40282-7, (2001) (PubMed).
Synonymes et noms alternatifs relatifs à SIGLEC12
sialic acid binding Ig like lectin 12 (gene/pseudogene) (SIGLEC12), sialic acid binding Ig like lectin 12 (SIGLEC12), sialic acid binding Ig-like lectin 12 (SIGLEC12), S2V, Siglec-XII, SIGLECL1, SLGProtein level used designations for SIGLEC12
- SIGLEC-like 1
- sialic acid-binding Ig-like lectin 12
- sialic acid-binding Ig-like lectin-like 1
- sialic acid binding immunoglobulin-like lectin-like protein 1
- sialic acid-binding lectin Siglec-L1
- siglec-12
- siglec-L1
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