SIGLEC7 Produits
(Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))
Catégories
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
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Catégories SIGLEC7 en vedette
SIGLEC7 Anticorps
High quality antibodies with extensive validation data.
SIGLEC7 Kits ELISA
Reliable ELISA kits for a wide range of species.
SIGLEC7 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
SIGLEC7 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (4)
N° du produit
ABIN7169566
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (3)
N° du produit
ABIN7438064
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC (p)
Validations
- (3)
N° du produit
ABIN388428
Quantité
400 μL
Fiche technique
Fiche technique
SIGLEC7 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (5)
N° du produit
ABIN6574286
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN5510679
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN4884544
Quantité
96 tests
Fiche technique
Fiche technique
SIGLEC7 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1319997
Quantité
2 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1319998
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
N° du produit
ABIN7092801
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits SIGLEC7
: "Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes." dans: Scientific reports, Vol. 7, pp. 45319, (2017) (PubMed).: "Siglec-1 is a novel dendritic cell receptor that mediates HIV-1 trans-infection through recognition of viral membrane gangliosides." dans: PLoS biology, Vol. 10, Issue 12, pp. e1001448, (2012) (PubMed).
: "Engagement of Siglec-7 receptor induces a pro-inflammatory response selectively in monocytes." dans: PLoS ONE, Vol. 7, Issue 9, pp. e45821, (2012) (PubMed).
: "Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids." dans: PLoS ONE, Vol. 6, Issue 9, pp. e24559, (2011) (PubMed).
: "Differences in the constitutive and SIV infection induced expression of Siglecs by hematopoietic cells from non-human primates." dans: Cellular immunology, Vol. 250, Issue 1-2, pp. 91-104, (2008) (PubMed).
: "Sialic acid-binding immunoglobulin-like lectin 7 mediates selective recognition of sialylated glycans expressed on Campylobacter jejuni lipooligosaccharides." dans: Infection and immunity, Vol. 74, Issue 7, pp. 4133-41, (2006) (PubMed).
: "High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family." dans: The Journal of biological chemistry, Vol. 278, Issue 5, pp. 3372-7, (2003) (PubMed).
: "Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanisms." dans: European journal of immunology, Vol. 33, Issue 6, pp. 1642-8, (2003) (PubMed).
Synonymes et noms alternatifs relatifs à SIGLEC7
sialic acid-binding Ig-like lectin 7 (LOC468976), sialic acid binding Ig like lectin 7 (SIGLEC7), AIRM1, CD328, CDw328, D-siglec, p75, p75/AIRM1, QA79, SIGLEC-7, SIGLEC7, SIGLEC19P, SIGLECP2Protein level used designations for SIGLEC7
- sialic acid binding Ig-like lectin 7
- AIRM-1
- QA79 membrane protein
- adhesion inhibitory receptor molecule 1, siglec-7
- sialic acid binding immunoglobulin-like lectin 7
- sialic acid-binding Ig-like lectin 7
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