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SIGLEC8 Produits

(Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))
Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM\\\\; MIM 603492) that mediates an association with SLAM-associated protein (SAP\\\\; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM, May 2010].

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Catégories SIGLEC8 en vedette

SIGLEC8 Anticorps

High quality antibodies with extensive validation data.

SIGLEC8 Kits ELISA

Reliable ELISA kits for a wide range of species.

SIGLEC8 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

SIGLEC8 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA
Validations
  • (1)
  • (1)
N° du produit ABIN565353
Quantité 50 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA
Validations
  • (2)
N° du produit ABIN525889
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA
Validations
  • (1)
N° du produit ABIN7186224
Quantité 100 μg
Fiche technique Fiche technique

SIGLEC8 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6970205
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6962264
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6959465
Quantité 96 tests
Fiche technique Fiche technique

SIGLEC8 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (2)
N° du produit ABIN7275591
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
N° du produit ABIN1320000
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
N° du produit ABIN7275601
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits SIGLEC8

Arakawa, Suzukawa, Ohshima, Tashimo, Asari, Matsui, Kobayashi, Shoji, Nagase, Ohta: "Expression of Siglec-8 is regulated by interleukin-5, and serum levels of soluble Siglec-8 may predict responsiveness of severe eosinophilic asthma to mepolizumab." dans: Allergology international : official journal of the Japanese Society of Allergology, Vol. 67S, pp. S41-S44, (2019) (PubMed).

Youngblood, Brock, Leung, Falahati, Bochner, Rasmussen, Peterson, Bebbington, Tomasevic: "Siglec-8 antibody reduces eosinophils and mast cells in a transgenic mouse model of eosinophilic gastroenteritis." dans: JCI insight, Vol. 4, Issue 19, (2019) (PubMed).

Yokoi, Choi, Hubbard, Lee, Canning, Lee, Ryu, von Gunten, Bickel, Hudson, Macglashan, Bochner: "Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement." dans: The Journal of allergy and clinical immunology, Vol. 121, Issue 2, pp. 499-505.e1, (2008) (PubMed).

von Gunten, Vogel, Schaub, Stadler, Miescher, Crocker, Simon: "Intravenous immunoglobulin preparations contain anti-Siglec-8 autoantibodies." dans: The Journal of allergy and clinical immunology, Vol. 119, Issue 4, pp. 1005-11, (2007) (PubMed).

Nutku, Aizawa, Hudson, Bochner: "Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis." dans: Blood, Vol. 101, Issue 12, pp. 5014-20, (2003) (PubMed).

Foussias, Yousef, Diamandis: "Molecular characterization of a Siglec8 variant containing cytoplasmic tyrosine-based motifs, and mapping of the Siglec8 gene." dans: Biochemical and biophysical research communications, Vol. 278, Issue 3, pp. 775-81, (2000) (PubMed).

Floyd, Ni, Cornish, Zeng, Liu, Carter, Steel, Crocker: "Siglec-8. A novel eosinophil-specific member of the immunoglobulin superfamily." dans: The Journal of biological chemistry, Vol. 275, Issue 2, pp. 861-6, (2000) (PubMed).

Kikly, Bochner, Freeman, Tan, Gallagher, Dalessio, Holmes, Abrahamson, Erickson-Miller, Murdock, Tachimoto, Schleimer, White: "Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils." dans: The Journal of allergy and clinical immunology, Vol. 105, Issue 6 Pt 1, pp. 1093-100, (2000) (PubMed).

Synonymes et noms alternatifs relatifs à SIGLEC8

sialic acid binding Ig like lectin 8 (SIGLEC8), sialic acid-binding Ig-like lectin 8 (LOC506364), SAF2, SIGLEC-8, SIGLEC8, SIGLEC8L

Protein level used designations for SIGLEC8

  • CDw329
  • SAF-2
  • sialic acid-binding Ig-like lectin 8
  • sialoadhesin family member 2
  • sialic acid binding Ig-like lectin 8
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