May be involved in chondrogenesis (cartilage development) during bone formation. Unlikely to play a role in sex determination but may function during testicular and ovarian differentiation (By similarity). Transcriptional activator. Acts early in neural crest formation, functioning redundantly with the other group E Sox factors sox8 and sox10 to induce neural crest progenitors. Induces sox10 expression downstream of wnt-signaling. Principally involved in development of the cranial neural crest, which is fated to form skeletal elements. Also required for otic placode specification during inner ear development.
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Yan, Willoughby, Liu, Crump, Wilson, Miller, Singer, Kimmel, Westerfield, Postlethwait: "A pair of Sox: distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development." dans: Development (Cambridge, England), Vol. 132, Issue 5, pp. 1069-83, (2005) (PubMed).
Synonymes et noms alternatifs relatifs à SOX9a
SRY (sex determining region Y)-box 9a (sox9a), jef, wu:fj17b12, zgc:111921