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SPTLC2 Produits

(serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2))
This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. [provided by RefSeq, Mar 2011].

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Catégories SPTLC2 en vedette

SPTLC2 Anticorps

High quality antibodies with extensive validation data.

SPTLC2 Kits ELISA

Reliable ELISA kits for a wide range of species.

SPTLC2 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

SPTLC2 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA
Validations
  • (1)
  • (3)
N° du produit ABIN564104
Quantité 50 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (3)
N° du produit ABIN7168896
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB
Validations
  • (4)
  • (1)
N° du produit ABIN1881828
Quantité 400 μL
Fiche technique Fiche technique

SPTLC2 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6959377
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6232466
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN5658720
Quantité 96 tests
Fiche technique Fiche technique

SPTLC2 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1321285
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1321284
Quantité 25 μg
Fiche technique Fiche technique
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7408900
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits SPTLC2

Wang, Robinet, Smith, Gulshan: "ORMDL orosomucoid-like proteins are degraded by free-cholesterol-loading-induced autophagy." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 12, pp. 3728-33, (2015) (PubMed).

Gupta, Gable, Alexaki, Chandris, Proia, Dunn, Harmon: "Expression of the ORMDLS, modulators of serine palmitoyltransferase, is regulated by sphingolipids in mammalian cells." dans: The Journal of biological chemistry, Vol. 290, Issue 1, pp. 90-8, (2015) (PubMed).

Rotthier, Auer-Grumbach, Janssens, Baets, Penno, Almeida-Souza, Van Hoof, Jacobs, De Vriendt, Schlotter-Weigel, Löscher, Vondráček, Seeman: "Mutations in the SPTLC2 subunit of serine palmitoyltransferase cause hereditary sensory and autonomic neuropathy type I." dans: American journal of human genetics, Vol. 87, Issue 4, pp. 513-22, (2010) (PubMed).

Han, Gupta, Gable, Niranjanakumari, Moitra, Eichler, Brown, Harmon, Dunn: "Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 20, pp. 8186-91, (2009) (PubMed).

Chen, Han, Dietrich, Dunn, Cahoon: "The essential nature of sphingolipids in plants as revealed by the functional identification and characterization of the Arabidopsis LCB1 subunit of serine palmitoyltransferase." dans: The Plant cell, Vol. 18, Issue 12, pp. 3576-93, (2007) (PubMed).

Hornemann, Wei, von Eckardstein: "Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?" dans: The Biochemical journal, Vol. 405, Issue 1, pp. 157-64, (2007) (PubMed).

Stachowitz, Alessandrini, Abeck, Ring, Behrendt: "Permeability barrier disruption increases the level of serine palmitoyltransferase in human epidermis." dans: The Journal of investigative dermatology, Vol. 119, Issue 5, pp. 1048-52, (2002) (PubMed).

Dias Neto, Correa, Verjovski-Almeida, Briones, Nagai, da Silva, Zago, Bordin, Costa, Goldman, Carvalho, Matsukuma, Baia, Simpson, Brunstein, de Oliveira, Bucher, Jongeneel, OHare, Soares, Brentani et al.: "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. ..." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 7, pp. 3491-6, (2000) (PubMed).

Synonymes et noms alternatifs relatifs à SPTLC2

serine palmitoyltransferase long chain base subunit 2 (SPTLC2), serine palmitoyltransferase 2 (LOC100446763), serine palmitoyltransferase long chain base subunit 2 (sptlc2), serine palmitoyltransferase, long chain base subunit 2 S homeolog (sptlc2.S), serine palmitoyltransferase, long chain base subunit 2a (sptlc2a), serine palmitoyltransferase, long chain base subunit 2 (Sptlc2), serine palmitoyltransferase long chain base subunit 2 (Sptlc2), AI173915, hLCB2a, HSN1C, LCB2, LCB2A, LCB2a, mKIAA0526, NSAN1C, Pomt2, SPT2, sptlc2, SPTLC2, zgc:110661

Protein level used designations for SPTLC2

  • LCB 2
  • SPT 2
  • long chain base biosynthesis protein 2a
  • serine palmitoyltransferase 2
  • serine palmitoyltransferase, subunit II
  • serine-palmitoyl-CoA transferase 2
  • serine palmitoyltransferase, long chain base subunit 2
  • serine palmitoyltransferase 2-like
  • LCB2a
  • long chain base biosynthesis protein 2
  • protein-O-mannosyltransferase 2
  • Long chain base biosynthesis protein 2
  • Long chain base biosynthesis protein 2a
  • Serine-palmitoyl-CoA transferase 2
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