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STAT2 Produits

(Signal Transducer and Activator of Transcription 2, 113kDa (STAT2))
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].

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Catégories STAT2 en vedette

STAT2 Anticorps

High quality antibodies with extensive validation data.

STAT2 Kits ELISA

Reliable ELISA kits for a wide range of species.

STAT2 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

STAT2 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (7)
N° du produit ABIN7434083
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Rat
Application WB, IHC, IP, ICC
Validations
  • (7)
N° du produit ABIN7443368
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
  • (6)
N° du produit ABIN738246
Quantité 100 μL
Fiche technique Fiche technique

STAT2 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
  • (3)
N° du produit ABIN5691024
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6970214
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6970213
Quantité 96 tests
Fiche technique Fiche technique

STAT2 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1321592
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7394858
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7406047
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits STAT2

Yamauchi, Takeuchi, Chihara, Honjoh, Kato, Yoshiki, Hotta, Sada: "STAT1 is essential for the inhibition of hepatitis C virus replication by interferon-λ but not by interferon-α." dans: Scientific reports, Vol. 6, pp. 38336, (2018) (PubMed).

Zhu, Wang, Zhou, Pan, Chen, Yang, Lv, Ye, Peng, Fang, Xiao: "Porcine Deltacoronavirus nsp5 Antagonizes Type I Interferon Signaling by Cleaving STAT2." dans: Journal of virology, Vol. 91, Issue 10, (2017) (PubMed).

Alves de Medeiros, Speeckaert, Desmet, Van Gele, De Schepper, Lambert: "JAK3 as an Emerging Target for Topical Treatment of Inflammatory Skin Diseases." dans: PloS one, Vol. 11, Issue 10, pp. e0164080, (2017) (PubMed).

Thacker, Berthier, Mattinzoli, Rastaldi, Kretzler, Kaplan: "The detrimental effects of IFN-α on vasculogenesis in lupus are mediated by repression of IL-1 pathways: potential role in atherogenesis and renal vascular rarefaction." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 7, pp. 4457-69, (2010) (PubMed).

Dolniak, Katsoulidis, Carayol, Altman, Redig, Tallman, Ueda, Watanabe-Fukunaga, Fukunaga, Platanias: "Regulation of arsenic trioxide-induced cellular responses by Mnk1 and Mnk2." dans: The Journal of biological chemistry, Vol. 283, Issue 18, pp. 12034-42, (2008) (PubMed).

Katsoulidis, Sassano, Majchrzak-Kita, Carayol, Yoon, Jordan, Druker, Fish, Platanias: "Suppression of interferon (IFN)-inducible genes and IFN-mediated functional responses in BCR-ABL-expressing cells." dans: The Journal of biological chemistry, Vol. 283, Issue 16, pp. 10793-803, (2008) (PubMed).

Jaitin, Schreiber: "Upregulation of a small subset of genes drives type I interferon-induced antiviral memory." dans: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 27, Issue 8, pp. 653-64, (2007) (PubMed).

Brierley, Fish: "Stats: multifaceted regulators of transcription." dans: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 25, Issue 12, pp. 733-44, (2005) (PubMed).

Brierley, Fish: "Functional relevance of the conserved DNA-binding domain of STAT2." dans: The Journal of biological chemistry, Vol. 280, Issue 13, pp. 13029-36, (2005) (PubMed).

Banninger, Reich: "STAT2 nuclear trafficking." dans: The Journal of biological chemistry, Vol. 279, Issue 38, pp. 39199-206, (2004) (PubMed).

Synonymes et noms alternatifs relatifs à STAT2

signal transducer and activator of transcription 2 (stat2), signal transducer and activator of transcription 2 (STAT2), AGAP000099-PA (STAT2), signal transducer and activator of transcription 2 (Stat2), 1600010G07Rik, AW496480, ISGF-3, p113, P113, stat2, STAT113, wu:fj84d07

Protein level used designations for STAT2

  • fj84d07
  • signal transducer and activator of transcription 2
  • signal transducer and activator of transcription (AGAP000099-PA)
  • interferon alpha induced transcriptional activator
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