Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation.
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Yeoh, Loh, Gooi, Singh, Gam: "Hydrophobic protein in colorectal cancer in relation to tumor stages and grades." dans: World journal of gastroenterology : WJG, Vol. 16, Issue 22, pp. 2754-63, (2010) (PubMed).
Chang, Ma, Gong, Cui, Liu, Zhou, Zhou, Wang: "SLP-2 overexpression is associated with tumour distant metastasis and poor prognosis in pulmonary squamous cell carcinoma." dans: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, Vol. 15, Issue 2, pp. 104-10, (2010) (PubMed).
Da Cruz, De Marchi, Frieden, Parone, Martinou, Demaurex: "SLP-2 negatively modulates mitochondrial sodium-calcium exchange." dans: Cell calcium, Vol. 47, Issue 1, pp. 11-8, (2010) (PubMed).
Grass, Preuss, Ahlgrimm, Fadle, Regitz, Pfoehler, Murawski, Pfreundschuh: "Association of a dominantly inherited hyperphosphorylated paraprotein target with sporadic and familial multiple myeloma and monoclonal gammopathy of undetermined significance: a case-control study." dans: The lancet oncology, Vol. 10, Issue 10, pp. 950-6, (2009) (PubMed).
Tondera, Grandemange, Jourdain, Karbowski, Mattenberger, Herzig, Da Cruz, Clerc, Raschke, Merkwirth, Ehses, Krause, Chan, Alexander, Bauer, Youle, Langer, Martinou: "SLP-2 is required for stress-induced mitochondrial hyperfusion." dans: The EMBO journal, Vol. 28, Issue 11, pp. 1589-600, (2009) (PubMed).
Kirchhof, Chau, Lemke, Vardhana, Darlington, Márquez, Taylor, Rizkalla, Blanca, Dustin, Madrenas: "Modulation of T cell activation by stomatin-like protein 2." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 3, pp. 1927-36, (2008) (PubMed).
Synonymes et noms alternatifs relatifs à STOML2
stomatin (EPB72)-like 2 (stoml2), stomatin like 2 (stoml2), stomatin like 2 (STOML2), stomatin like 2 L homeolog (stoml2.L), stomatin (Epb7.2)-like 2 (Stoml2), stomatin like 2 (Stoml2), 0610038F01Rik, MGC116533, MSLP2, SLP-2, zgc:63505