SUPT5H Produits
(Transcription Elongation Factor SPT5 (SUPT5H))
Catégories
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV- 1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.
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Catégories SUPT5H en vedette
SUPT5H Anticorps
High quality antibodies with extensive validation data.
SUPT5H Kits ELISA
Reliable ELISA kits for a wide range of species.
SUPT5H Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
SUPT5H recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IF, IHC (p)
Validations
- (4)
N° du produit
ABIN520620
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Application
WB, IHC, IHC (p)
Validations
- (3)
N° du produit
ABIN6735860
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Rabbit, Zebrafish (Danio rerio)
Application
WB, IHC
Validations
- (4)
N° du produit
ABIN2777903
Quantité
100 μL
Fiche technique
Fiche technique
SUPT5H recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Validations
N° du produit
ABIN1162213
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Validations
N° du produit
ABIN1162214
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Chicken
Analytical Method
Validations
N° du produit
ABIN1162212
Quantité
96 tests
Fiche technique
Fiche technique
SUPT5H recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1321917
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3095662
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3131899
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits SUPT5H
: "Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism." dans: eLife, Vol. 4, pp. e06535, (2015) (PubMed).: "Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway." dans: Nature communications, Vol. 3, pp. 976, (2012) (PubMed).
: "A role for the RNA pol II-associated PAF complex in AID-induced immune diversification." dans: The Journal of experimental medicine, Vol. 209, Issue 11, pp. 2099-111, (2012) (PubMed).
: "Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 "cherubism" mice." dans: Cell, Vol. 128, Issue 1, pp. 71-83, (2007) (PubMed).
: "Differential regulation of NF-kappaB by elongation factors is determined by core promoter type." dans: Molecular and cellular biology, Vol. 27, Issue 14, pp. 5246-59, (2007) (PubMed).
Synonymes et noms alternatifs relatifs à SUPT5H
SPT5 homolog, DSIF elongation factor subunit (SUPT5H), transcription elongation factor SPT5 (LOC413814), Transcription elongation factor Spt5 (AT2G34210), transcription elongation factor Spt5 (spt5), transcription elongation factor spt5 (MGYG_08422), transcription elongation factor spt5 (TERG_05483), hypothetical protein (PGTG_18458), SPT5 homolog, DSIF elongation factor subunit (supt5h), SPT5 homolog, DSIF elongation factor subunit (Supt5h), SPT5 homolog, DSIF elongation factor subunit S homeolog (supt5h.S), CG7626 gene product from transcript CG7626-RA (Spt5), Transcription elongation factor SPT5 (spt-5), transcription elongation factor (SPT5), CaO19.1453, CG7626, dDSIF, Dmel\\CG7626, DSIF, Dspt5, dSpt5, etID10129.15, etID37101.15, F13P17.5, F13P17_5, fb37g01, fb95e05, fog, foggy, SPT5, Spt5, spt5, SPT5H, spt5h, Tat-CT1, tat-ct1, wu:fb37g01, wu:fb95e05, wu:fc10f02Protein level used designations for SUPT5H
- DRB sensitivity-inducing factor 160 kDa subunit
- DRB sensitivity-inducing factor large subunit
- DSIF large subunit
- DSIF p160
- Tat-cotransactivator 1 protein
- hSPT5
- transcription elongation factor SPT5
- transcription elongation factor Spt5
- transcription elongation factor spt5
- protein foggy
- transcription elongation regulator foggy
- CG7626-PA
- Spt5-PA
- Chromatin elongation factor SPT5
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