TAB1 Produits
(TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1))
Catégories
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
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Catégories TAB1 en vedette
TAB1 Anticorps
High quality antibodies with extensive validation data.
TAB1 Kits ELISA
Reliable ELISA kits for a wide range of species.
TAB1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
TAB1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IF, PLA
Validations
- (6)
N° du produit
ABIN564552
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (4)
N° du produit
ABIN7171965
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
N° du produit
ABIN523851
Quantité
200 μL
Fiche technique
Fiche technique
TAB1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6970603
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6229502
Quantité
96 tests
Fiche technique
Fiche technique
TAB1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7125344
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1310231
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1310229
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits TAB1
: "MicroRNA 27a-3p Regulates Antimicrobial Responses of Murine Macrophages Infected by Mycobacterium avium subspecies paratuberculosis by Targeting Interleukin-10 and TGF-β-Activated Protein Kinase 1 ..." dans: Frontiers in immunology, Vol. 8, pp. 1915, (2017) (PubMed).: "Insights into O-linked N-acetylglucosamine ([0-9]O-GlcNAc) processing and dynamics through kinetic analysis of O-GlcNAc transferase and O-GlcNAcase activity on protein substrates." dans: The Journal of biological chemistry, Vol. 287, Issue 19, pp. 15395-408, (2012) (PubMed).
: "PRAK is essential for ras-induced senescence and tumor suppression." dans: Cell, Vol. 128, Issue 2, pp. 295-308, (2007) (PubMed).
: "Determinants that control the specific interactions between TAB1 and p38alpha." dans: Molecular and cellular biology, Vol. 26, Issue 10, pp. 3824-34, (2006) (PubMed).
: "TAK1-binding protein 1 is a pseudophosphatase." dans: The Biochemical journal, Vol. 399, Issue 3, pp. 427-34, (2006) (PubMed).
: "Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex ..." dans: The Journal of biological chemistry, Vol. 280, Issue 8, pp. 7359-68, (2005) (PubMed).
: "Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice." dans: Cancer research, Vol. 64, Issue 20, pp. 7183-90, (2004) (PubMed).
: "Toll-like receptor signalling." dans: Nature reviews. Immunology, Vol. 4, Issue 7, pp. 499-511, (2004) (PubMed).
: "TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2." dans: Nature, Vol. 416, Issue 6878, pp. 345-7, (2002) (PubMed).
: "Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol." dans: Molecular and cellular biology, Vol. 22, Issue 20, pp. 7158-67, (2002) (PubMed).
Synonymes et noms alternatifs relatifs à TAB1
TGF-beta activated kinase 1 (MAP3K7) binding protein 1 (TAB1), TGF-beta activated kinase 1/MAP3K7 binding protein 1 (Tab1), 3'-Tab1, 2310012M03Rik, b2b449Clo, MAP3K7IP1, Map3k7ip1Protein level used designations for TAB1
- TAK1-binding protein 1
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
- mitogen-activated protein kinase kinase kinase 7-interacting protein 1
- transforming growth factor beta-activated kinase-binding protein 1
- TGF-beta-activated kinase 1-binding protein 1
- Tak1-binding protein 1
- beta activated kinase-1 binding protein-1
- mitogen activated protein kinase kinase kinase 7 interacting protein 1
- mitogen-activated protein kinase kinase kinase 7 interacting protein 1
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