TCF3 Produits
(Transcription Factor 3 (E2A Immunoglobulin Enhancer Binding Factors E12/E47) (TCF3))
Catégories
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1\;19), with PBX1), childhood leukemia (t(19\;19), with TFPT) and acute leukemia (t(12\;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011].
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Catégories TCF3 en vedette
TCF3 Anticorps
High quality antibodies with extensive validation data.
TCF3 Kits ELISA
Reliable ELISA kits for a wide range of species.
TCF3 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
TCF3 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse
Application
WB, FACS, IHC (p)
Validations
- (5)
N° du produit
ABIN657912
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
- (3)
N° du produit
ABIN563112
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, FACS
Validations
- (2)
- (2)
N° du produit
ABIN1724729
Quantité
100 μL
Fiche technique
Fiche technique
TCF3 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6970767
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
N° du produit
ABIN5661964
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Validations
N° du produit
ABIN1162300
Quantité
96 tests
Fiche technique
Fiche technique
TCF3 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1322367
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7422253
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3133067
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits TCF3
: "Sustained endoplasmic reticulum stress inhibits hepatocyte proliferation via downregulation of c-Met expression." dans: Molecular and cellular biochemistry, Vol. 389, Issue 1-2, pp. 151-8, (2014) (PubMed).: "T cell factor 4 is a pro-catabolic and apoptotic factor in human articular chondrocytes by potentiating nuclear factor ?B signaling." dans: The Journal of biological chemistry, Vol. 288, Issue 24, pp. 17552-8, (2013) (PubMed).
: "Synaptic cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses." dans: The Journal of biological chemistry, Vol. 284, Issue 42, pp. 29146-57, (2009) (PubMed).
: "Accelerated Notch-dependent degradation of E47 proteins in aged B cell precursors is associated with increased ERK MAPK activation." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 6, pp. 3521-9, (2007) (PubMed).
: "Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes." dans: The Journal of biological chemistry, Vol. 279, Issue 43, pp. 45028-35, (2004) (PubMed).
: "Positive regulation of myogenic bHLH factors and skeletal muscle development by the cell surface receptor CDO." dans: Developmental cell, Vol. 7, Issue 6, pp. 843-54, (2004) (PubMed).
: "Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities." dans: The EMBO journal, Vol. 22, Issue 21, pp. 5780-92, (2003) (PubMed).
: "Inhibition of Tcf3 binding by I-mfa domain proteins." dans: Molecular and cellular biology, Vol. 21, Issue 5, pp. 1866-73, (2001) (PubMed).
: "The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function." dans: The Journal of biological chemistry, Vol. 275, Issue 43, pp. 33567-73, (2000) (PubMed).
: "Both E12 and E47 allow commitment to the B cell lineage." dans: Immunity, Vol. 6, Issue 2, pp. 145-54, (1997) (PubMed).
Synonymes et noms alternatifs relatifs à TCF3
transcription factor 3 (TCF3), transcription factor 3b (tcf3b), transcription factor 3 (Tcf3), transcription factor 3 L homeolog (tcf3.L), transcription factor E2a (tcfe2a), A1, AA408400, ALF2, AW209082, bHLHb21, bhlhb21, E2A, e2a, E12, E12/E47, E47, G12, ITF1, itf1, ME2, Pan1, Pan2, TCF-3, tcf3a, TCF7L1, Tcfe2a, tcfe2a, VDIR, vdir, XE3, xtcf-3, xtcf3, zgc:113045Protein level used designations for TCF3
- VDR interacting repressor
- class B basic helix-loop-helix protein 21
- helix-loop-helix protein HE47
- immunoglobulin transcription factor 1
- kappa-E2-binding factor
- negative vitamin D response element-binding protein
- transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
- transcription factor E2-alpha
- transcription factor ITF-1
- vitamin D receptor-interacting repressor
- transcription factor 3
- TCF-3
- immunoglobulin enhancer-binding factor E12/E47
- transcription factor A1
- transcription factor E2a
- pancreas specific transcription factor 1c
- transcription regulator Pan
- transcription factor XE12/XE47
- class A basic helix-loop-helix transcription factor G12
- helix-loop-helix protein E12
- helix-loop-helix protein E47
- transcription factor 7-like 1 (T-cell specific, HMG-box)
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