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TCRb Anticorps

(T Cell Receptor beta Chain (TCRb))
T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes several trypsinogen genes. [provided by RefSeq, Jul 2008]

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Catégories TCRb en vedette

TCRb Anticorps

High quality antibodies with extensive validation data.

TCRb recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, FACS
Validations
  • (6)
N° du produit ABIN656127
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human
Application ELISA, WB, IHC
Validations
  • (3)
N° du produit ABIN7171289
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application IHC, IF
Validations
  • (3)
N° du produit ABIN7075813
Quantité 100 μL
Fiche technique Fiche technique

Synonymes et noms alternatifs relatifs à TCRb

T cell receptor beta chain (Tcrb), T-cell receptor beta locus (TRB), TCRB, TCRbeta, Tib, TRB@

Protein level used designations for TCRb

  • T-cell receptor beta chain
  • T-cell antigen receptor, beta polypeptide, T-cell receptor, beta cluster
  • T-cell receptor, beta cluster
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