TDG Produits
(Thymine-DNA Glycosylase (TDG))
Catégories
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008].
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Catégories TDG en vedette
TDG Anticorps
High quality antibodies with extensive validation data.
TDG Kits ELISA
Reliable ELISA kits for a wide range of species.
TDG Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
TDG recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
N° du produit
ABIN7153379
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Application
WB, FACS
Validations
- (2)
N° du produit
ABIN390559
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, FACS
Validations
- (2)
N° du produit
ABIN390560
Quantité
400 μL
Fiche technique
Fiche technique
TDG recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6959949
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Validations
N° du produit
ABIN1134027
Quantité
96 tests
Fiche technique
Fiche technique
TDG recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN1098673
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1322426
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1785499
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits TDG
: "Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability." dans: Genome biology, Vol. 19, Issue 1, pp. 37, (2018) (PubMed).: "A G-quadruplex-selective luminescent probe with an anchor tail for the switch-on detection of thymine DNA glycosylase activity." dans: Biosensors & bioelectronics, Vol. 86, pp. 849-57, (2016) (PubMed).
: "TGFβ promotes mesenchymal phenotype of pancreatic cancer cells, in part, through epigenetic activation of VAV1." dans: Oncogene, Vol. 36, Issue 16, pp. 2202-2214, (2016) (PubMed).
: "Base excision repair of tandem modifications in a methylated CpG dinucleotide." dans: The Journal of biological chemistry, Vol. 289, Issue 20, pp. 13996-4008, (2014) (PubMed).
: "Crystal structure of thymine DNA glycosylase conjugated to SUMO-1." dans: Nature, Vol. 435, Issue 7044, pp. 979-82, (2005) (PubMed).
: "Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover." dans: The EMBO journal, Vol. 21, Issue 6, pp. 1456-64, (2002) (PubMed).
: "Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase." dans: The Journal of biological chemistry, Vol. 271, Issue 22, pp. 12767-74, (1996) (PubMed).
: "Efficient removal of uracil from G.U mispairs by the mismatch-specific thymine DNA glycosylase from HeLa cells." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 5, pp. 1642-6, (1994) (PubMed).
Synonymes et noms alternatifs relatifs à TDG
thymine DNA glycosylase (TDG), thymine DNA glycosylase, tandem duplicate 1 (tdg.1), putative g/t mismatch-specific thymine DNA glycosylase (Smp_149220), G/T mismatch-specific thymine DNA glycosylase (Tsp_05734), thymine DNA glycosylase S homeolog (tdg.S), thymine DNA glycosylase (tdg), thymine DNA glycosylase (Tdg), thymine-DNA glycosylase (Tdg), 5-MCDG, E130317C12Rik, hTDG, JZA-3, Jza1, MGC82456, MGC89441, wu:fb44b11, zgc:110622Protein level used designations for TDG
- G/T mismatch-specific thymine DNA glycosylase
- G/T mismatch DNA glycosylase
- G/t mismatch-specific thymine DNA glycosylase
- thymine-DNA glycosylase
- G/T mismatch-specific thymine DNA glycosylase-like
- g/T mismatch-specific thymine DNA glycosylase-like
- C-JUN leucine zipper interactive protein JZA-3
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