TDP1 Produits
(Tyrosyl-DNA Phosphodiesterase 1 (TDP1))
Catégories
The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq, Jul 2008].
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Catégories TDP1 en vedette
TDP1 Anticorps
High quality antibodies with extensive validation data.
TDP1 Kits ELISA
Reliable ELISA kits for a wide range of species.
TDP1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
TDP1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IP, IF
Validations
- (4)
N° du produit
ABIN949469
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, IP
Validations
- (3)
N° du produit
ABIN7174129
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IF, IHC (p), ICC
Validations
- (3)
N° du produit
ABIN2857076
Quantité
100 μL
Fiche technique
Fiche technique
TDP1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6960333
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN5564588
Quantité
96 tests
Fiche technique
Fiche technique
TDP1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
N° du produit
ABIN1322434
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1322436
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN2132102
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits TDP1
: "Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan." dans: Molecular cancer therapeutics, Vol. 14, Issue 2, pp. 575-85, (2015) (PubMed).: "PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage." dans: Nucleic acids research, Vol. 42, Issue 7, pp. 4435-49, (2014) (PubMed).
: "Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes." dans: Nature neuroscience, Vol. 17, Issue 6, pp. 813-21, (2014) (PubMed).
: "Role of tyrosyl-DNA phosphodiesterase 1 and inter-players in regulation of tumor cell sensitivity to topoisomerase I inhibition." dans: Biochemical pharmacology, Vol. 83, Issue 1, pp. 27-36, (2011) (PubMed).
: "In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation." dans: DNA repair, Vol. 8, Issue 5, pp. 654-63, (2009) (PubMed).
: "Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK." dans: The EMBO journal, Vol. 28, Issue 23, pp. 3667-80, (2009) (PubMed).
: "Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies." dans: The Journal of biological chemistry, Vol. 284, Issue 13, pp. 8516-24, (2009) (PubMed).
: "TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo." dans: The EMBO journal, Vol. 26, Issue 22, pp. 4720-31, (2007) (PubMed).
: "Aprataxin, causative gene product for EAOH/AOA1, repairs DNA single-strand breaks with damaged 3'-phosphate and 3'-phosphoglycolate ends." dans: Nucleic acids research, Vol. 35, Issue 11, pp. 3797-809, (2007) (PubMed).
Synonymes et noms alternatifs relatifs à TDP1
tyrosyl-DNA phosphodiesterase 1 (TDP1), tyrosyl-DNA Phosphodiesterase (Tdp1) (Tc00.1047053511191.10), tyrosyl-DNA phosphodiesterase 1 (Tdp1), tyrosyl-DNA phosphodiesterase 1 L homeolog (tdp1.L), tyrosyl-DNA phosphodiesterase 1 (tdp1), tyrosyl-DNA phosphodiesterase-like protein (TDP1), tyrosyl-DNA phosphodiesterase 1 (PTRG_11198), tyrosyl-DNA phosphodiesterase 1 (MCYG_02121), tyrosyl-DNA phosphodiesterase 1 (MGYG_03035), 2810481F14Rik, 4921509N21Rik, AI838772, AW493413, E430034L06Rik, F8M21.60, F8M21_60, MGC83708, MLZ-501, SCAN1, tdp1, TDP1, tyrosyl-DNA phosphodiesterase 1Protein level used designations for TDP1
- tyr-DNA phosphodiesterase 1
- tyrosyl-DNA Phosphodiesterase (Tdp1)
- protein expressed in male leptotene and zygotene spermatocytes 501
- tyrosyl-DNA phodphodiesterase 1
- tyrosyl-DNA phosphodiesterase 1
- tyrosyl-DNA phosphodiesterase 1-like
- Tyrosyl-DNA phosphodiesterase 1-like protein
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