TFEB Produits
(Transcription Factor EB (TFEB))
Catégories
Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.
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Catégories TFEB en vedette
TFEB Anticorps
High quality antibodies with extensive validation data.
TFEB Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
TFEB recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (1)
- (5)
N° du produit
ABIN563503
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Cow, Dog, Goat, Horse, Human, Rabbit
Application
WB
Validations
- (5)
N° du produit
ABIN2787554
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (3)
N° du produit
ABIN7172536
Quantité
100 μg
Fiche technique
Fiche technique
TFEB recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Semi-Quantitative DNA-Binding ELISA
Validations
- (2)
- (2)
N° du produit
ABIN5526704
Quantité
96 tests
Fiche technique
Fiche technique
TFEB recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7125448
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1786750
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
- (1)
N° du produit
ABIN2733467
Quantité
50 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits TFEB
: "Lysosomal sequestration of weak base drugs, lysosomal biogenesis, and cell cycle alteration." dans: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, Vol. 153, pp. 113328, (2022) (PubMed).: "Restoring autophagic flux attenuates cochlear spiral ganglion neuron degeneration by promoting TFEB nuclear translocation via inhibiting MTOR." dans: Autophagy, Vol. 15, Issue 6, pp. 998-1016, (2019) (PubMed).
: "HSPA5 negatively regulates lysosomal activity through ubiquitination of MUL1 in head and neck cancer." dans: Autophagy, Vol. 14, Issue 3, pp. 385-403, (2019) (PubMed).
: "MITA modulated autophagy flux promotes cell death in breast cancer cells." dans: Cellular signalling, Vol. 35, pp. 73-83, (2018) (PubMed).
: "Altered Differentiation Potential of Gaucher's Disease iPSC Neuronal Progenitors due to Wnt/β-Catenin Downregulation." dans: Stem cell reports, Vol. 9, Issue 6, pp. 1853-1867, (2017) (PubMed).
: "TFEB regulates PER3 expression via glucose-dependent effects on CLOCK/BMAL1." dans: The international journal of biochemistry & cell biology, Vol. 78, pp. 31-42, (2017) (PubMed).
: "Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals." dans: Nature communications, Vol. 7, pp. 10944, (2016) (PubMed).
: "A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition." dans: Autophagy, Vol. 12, Issue 8, pp. 1372-89, (2016) (PubMed).
: "Neuraminidase of Influenza A Virus Binds Lysosome-Associated Membrane Proteins Directly and Induces Lysosome Rupture." dans: Journal of virology, Vol. 89, Issue 20, pp. 10347-58, (2015) (PubMed).
: "Aberrant differentiation of Tsc2-deficient teratomas associated with activation of the mTORC1-TFE3 pathway." dans: Oncology reports, Vol. 34, Issue 5, pp. 2251-8, (2015) (PubMed).
Synonymes et noms alternatifs relatifs à TFEB
transcription factor EB (TFEB), transcription factor EB (tfeb), transcription factor EB (Tfeb), alphatfeb, ALPHATFEB, BHLHE35, bHLHe35, MGC145796, tcfeb, TCFEB, Tcfeb, TFEBProtein level used designations for TFEB
- transcription factor EB
- transcription factor EB-like
- T-cell transcription factor EB
- class E basic helix-loop-helix protein 35
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