Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

TFEB Produits

(Transcription Factor EB (TFEB))

Catégories

Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.

antibodies-online.com est synonyme de produits de recherche de haute qualité. Cherchez, trouvez et commandez des outils avec des données de validation étendues, des images, des références. Notre service clientèle scientifique est toujours à votre disposition si vous avez des questions sur la sélection ou l'application de nos produits.

Catégories TFEB en vedette

TFEB Anticorps

High quality antibodies with extensive validation data.

TFEB Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

TFEB recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, IF
Validations
  • (1)
  • (5)
N° du produit ABIN563503
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA
Validations
  • (8)
N° du produit ABIN184741
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Cow, Dog, Goat, Horse, Human, Rabbit
Application WB
Validations
  • (5)
N° du produit ABIN2787554
Quantité 100 μL
Fiche technique Fiche technique

TFEB recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Semi-Quantitative DNA-Binding ELISA
Validations
  • (2)
  • (2)
N° du produit ABIN5526704
Quantité 96 tests
Fiche technique Fiche technique

TFEB recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7125448
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1786750
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
  • (1)
N° du produit ABIN2733467
Quantité 50 μg
Fiche technique Fiche technique

Dernières publications sur nos produits TFEB

Mlejnek, Havlasek, Pastvova, Dolezel, Dostalova: "Lysosomal sequestration of weak base drugs, lysosomal biogenesis, and cell cycle alteration." dans: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, Vol. 153, pp. 113328, (2022) (PubMed).

Ye, Wang, Hu, Shen, Fan, Chen, Ma, Wu, Xiang: "Restoring autophagic flux attenuates cochlear spiral ganglion neuron degeneration by promoting TFEB nuclear translocation via inhibiting MTOR." dans: Autophagy, Vol. 15, Issue 6, pp. 998-1016, (2019) (PubMed).

Kim, Kim, Kim, Kim, Han, Byeon, Lee, Kim: "HSPA5 negatively regulates lysosomal activity through ubiquitination of MUL1 in head and neck cancer." dans: Autophagy, Vol. 14, Issue 3, pp. 385-403, (2019) (PubMed).

Bhatelia, Singh, Prajapati, Sripada, Roy, Singh: "MITA modulated autophagy flux promotes cell death in breast cancer cells." dans: Cellular signalling, Vol. 35, pp. 73-83, (2018) (PubMed).

Awad, Panicker, Deranieh, Srikanth, Brown, Voit, Peesay, Park, Zambidis, Feldman: "Altered Differentiation Potential of Gaucher's Disease iPSC Neuronal Progenitors due to Wnt/β-Catenin Downregulation." dans: Stem cell reports, Vol. 9, Issue 6, pp. 1853-1867, (2017) (PubMed).

Luo, Ma, Yang, Wang, Zhang, Zhang, Liu, Liu: "TFEB regulates PER3 expression via glucose-dependent effects on CLOCK/BMAL1." dans: The international journal of biochemistry & cell biology, Vol. 78, pp. 31-42, (2017) (PubMed).

Nakamura, Karalay, Jäger, Horikawa, Klein, Nakamura, Latza, Templer, Dieterich, Antebi: "Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals." dans: Nature communications, Vol. 7, pp. 10944, (2016) (PubMed).

Song, Sun, Peluso, Zeng, Yu, Lu, Xu, Wang, Liu, Huang, Chen, Durairajan, Zhang, Zhou, Zhang, Lu, Ballabio, Medina, Guo, Li: "A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition." dans: Autophagy, Vol. 12, Issue 8, pp. 1372-89, (2016) (PubMed).

Ju, Yan, Liu, Li, Sheng, Zhang, Li, Liang, Huang, Liu, Zhao, Zhang, Zou, Du, Zhong, Zhou, Yang, Lu, Tian, Li, Zhang, Jin, Jiang: "Neuraminidase of Influenza A Virus Binds Lysosome-Associated Membrane Proteins Directly and Induces Lysosome Rupture." dans: Journal of virology, Vol. 89, Issue 20, pp. 10347-58, (2015) (PubMed).

Kawano, Ito, Kanai, Nakamura, Tada, Takai, Horie, Kobayashi, Hino: "Aberrant differentiation of Tsc2-deficient teratomas associated with activation of the mTORC1-TFE3 pathway." dans: Oncology reports, Vol. 34, Issue 5, pp. 2251-8, (2015) (PubMed).

Synonymes et noms alternatifs relatifs à TFEB

transcription factor EB (TFEB), transcription factor EB (tfeb), transcription factor EB (Tfeb), alphatfeb, ALPHATFEB, BHLHE35, bHLHe35, MGC145796, tcfeb, TCFEB, Tcfeb, TFEB

Protein level used designations for TFEB

  • transcription factor EB
  • transcription factor EB-like
  • T-cell transcription factor EB
  • class E basic helix-loop-helix protein 35
Vous êtes ici:
Support technique