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TIRAP Produits

(Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein (TIRAP))

Catégories

The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants\; however, not all variants have been fully described. [provided by RefSeq, Jul 2008].

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Catégories TIRAP en vedette

TIRAP Anticorps

High quality antibodies with extensive validation data.

TIRAP Kits ELISA

Reliable ELISA kits for a wide range of species.

TIRAP Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

TIRAP recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, IHC (p), IHC (fro), ICC
Validations
  • (8)
N° du produit ABIN7441712
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IF
Validations
  • (1)
  • (5)
N° du produit ABIN6149192
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (3)
N° du produit ABIN7172290
Quantité 100 μL
Fiche technique Fiche technique

TIRAP recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6970732
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6960023
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6223712
Quantité 96 tests
Fiche technique Fiche technique

TIRAP recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1322812
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7409917
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN2132191
Quantité 50 μg
Fiche technique Fiche technique

Dernières publications sur nos produits TIRAP

Blanchard, Loomis, Bhosle, Vanover, Baumhof, Pitard, Zurla, Santangelo: "Proximity Ligation Assays for In Situ Detection of Innate Immune Activation: Focus on In Vitro-Transcribed mRNA." dans: Molecular therapy. Nucleic acids, Vol. 14, pp. 52-66, (2019) (PubMed).

Du, Qiao, Chen, Chen, Liu, Lin, Wang, Xie: "Toll-Like Receptor 4 Mediates Methamphetamine-Induced Neuroinflammation through Caspase-11 Signaling Pathway in Astrocytes." dans: Frontiers in molecular neuroscience, Vol. 10, pp. 409, (2017) (PubMed).

Rolf, Kariminia, Ivison, Reid, Schultz: "Heterodimer-specific TLR2 stimulation results in divergent functional outcomes in B-cell precursor acute lymphoblastic leukemia." dans: European journal of immunology, Vol. 45, Issue 7, pp. 1980-90, (2015) (PubMed).

Wang, Schwab, Fan, Seagroves, Buolamwini: "Chemoprevention Activity of Dipyridamole in the MMTV-PyMT Transgenic Mouse Model of Breast Cancer." dans: Cancer prevention research (Philadelphia, Pa.), Vol. 6, Issue 5, pp. 437-47, (2013) (PubMed).

Nguyen, Kim, Kim, Le, Kim, Kang, Hasegawa, Kanaho, Jou, Lee et al.: "Phosphatidylinositol 4-phosphate 5-kinase ? facilitates Toll-like receptor 4-mediated microglial inflammation through regulation of the Toll/interleukin-1 receptor domain-containing adaptor protein ..." dans: The Journal of biological chemistry, Vol. 288, Issue 8, pp. 5645-59, (2013) (PubMed).

Farina, Krumbholz, Giese, Hartmann, Aloisi, Meinl: "Preferential expression and function of Toll-like receptor 3 in human astrocytes." dans: Journal of neuroimmunology, Vol. 159, Issue 1-2, pp. 12-9, (2005) (PubMed).

Cascalho: "Advantages and disadvantages of cytidine deamination." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 11, pp. 6513-8, (2004) (PubMed).

Andreakos, Sacre, Smith, Lundberg, Kiriakidis, Stonehouse, Monaco, Feldmann, Foxwell: "Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP." dans: Blood, Vol. 103, Issue 6, pp. 2229-37, (2004) (PubMed).

Vogel, Fitzgerald, Fenton: "TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression." dans: Molecular interventions, Vol. 3, Issue 8, pp. 466-77, (2004) (PubMed).

McGettrick, ONeill: "The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction." dans: Molecular immunology, Vol. 41, Issue 6-7, pp. 577-82, (2004) (PubMed).

Synonymes et noms alternatifs relatifs à TIRAP

toll-interleukin 1 receptor (TIR) domain containing adaptor protein (tirap), TIR domain containing adaptor protein (TIRAP), toll-interleukin 1 receptor (TIR) domain containing adaptor protein L homeolog (tirap.L), TIR domain containing adaptor protein (Tirap), toll-interleukin 1 receptor (TIR) domain-containing adaptor protein (Tirap), AA407980, BACTS1, C130027E04Rik, mal, Mal, MyD88-2, Tlr4ap, wyatt, Wyatt

Protein level used designations for TIRAP

  • MyD88 adapter-like protein
  • Toll-interleukin 1 receptor domain-containing adaptor protein
  • toll/interleukin-1 receptor domain-containing adapter protein
  • TIR domain-containing adaptor protein
  • Toll-like receptor adaptor protein
  • adapter protein wyatt
  • adaptor protein Wyatt
  • toll-interleukin 1 receptor domain-containing adaptor protein
  • TIR domain-containing adapter protein
  • Toll-like receptor 4 adaptor protein
  • myD88 adapter-like protein
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