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TNFSF9 Produits

(Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9))

Catégories

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008].

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Catégories TNFSF9 en vedette

TNFSF9 Anticorps

High quality antibodies with extensive validation data.

TNFSF9 Kits ELISA

Reliable ELISA kits for a wide range of species.

TNFSF9 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

TNFSF9 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse, Rat
Application WB, ELISA, ICC, IF (p), IF (cc), IHC (p), IHC (fro)
Validations
  • (3)
  • (1)
N° du produit ABIN705056
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (7)
N° du produit ABIN7441109
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (4)
N° du produit ABIN7443173
Quantité 100 μL
Fiche technique Fiche technique

TNFSF9 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6970952
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6960265
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN4881698
Quantité 96 tests
Fiche technique Fiche technique

TNFSF9 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (4)
N° du produit ABIN7273929
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Cynomolgus
Source HEK-293 Cells
Validations
  • (3)
N° du produit ABIN7273927
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
N° du produit ABIN7273928
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits TNFSF9

Cochain, Vafadarnejad, Arampatzi, Pelisek, Winkels, Ley, Wolf, Saliba, Zernecke: "Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine Atherosclerosis." dans: Circulation research, Vol. 122, Issue 12, pp. 1661-1674, (2019) (PubMed).

Gilbreth, Oganesyan, Amdouni, Novarra, Grinberg, Barnes, Baca: "Crystal structure of the human 4-1BB/4-1BBL complex." dans: The Journal of biological chemistry, Vol. 293, Issue 25, pp. 9880-9891, (2018) (PubMed).

Won, Cha, Byun, Kim, Shin, Ahn, Kim, Rice, Walz, Kwon, Cho: "The structure of the trimer of human 4-1BB ligand is unique among members of the tumor necrosis factor superfamily." dans: The Journal of biological chemistry, Vol. 285, Issue 12, pp. 9202-10, (2010) (PubMed).

Gullo, Koh, Pang, Ho, Tan, Schwarz: "Inhibition of proliferation and induction of apoptosis in multiple myeloma cell lines by CD137 ligand signaling." dans: PLoS ONE, Vol. 5, Issue 5, pp. e10845, (2010) (PubMed).

Ek, Björck, Högerkorp, Nordenskjöld, Porwit-MacDonald, Borrebaeck: "Mantle cell lymphomas acquire increased expression of CCL4, CCL5 and 4-1BB-L implicated in cell survival." dans: International journal of cancer, Vol. 118, Issue 8, pp. 2092-7, (2006) (PubMed).

Rabu, Quéméner, Jacques, Echasserieau, Vusio, Lang: "Production of recombinant human trimeric CD137L (4-1BBL). Cross-linking is essential to its T cell co-stimulation activity." dans: The Journal of biological chemistry, Vol. 280, Issue 50, pp. 41472-81, (2005) (PubMed).

Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." dans: Genome research, Vol. 14, Issue 10B, pp. 2121-7, (2004) (PubMed).

Xu, Zhang, Han, Zhang: "[Binding between alpha 1A-adrenergic receptor and segment of bone morphogenetic protein-1 in human embryonic cell 293]." dans: Sheng li xue bao : [Acta physiologica Sinica], Vol. 55, Issue 6, pp. 692-8, (2003) (PubMed).

Akiba, Miyahira, Atsuta, Takeda, Nohara, Futagawa, Matsuda, Aoki, Yagita, Okumura: "Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis." dans: The Journal of experimental medicine, Vol. 191, Issue 2, pp. 375-80, (2000) (PubMed).

Melero, Bach, Hellström, Aruffo, Mittler, Chen: "Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: synergy with the CD28 co-stimulatory pathway." dans: European journal of immunology, Vol. 28, Issue 3, pp. 1116-21, (1998) (PubMed).

Synonymes et noms alternatifs relatifs à TNFSF9

TNF superfamily member 9 (Tnfsf9), TNF superfamily member 9 (LOC476729), TNF superfamily member 9 (TNFSF9), tumor necrosis factor (ligand) superfamily, member 9 (Tnfsf9), 4-1BB-L, 4-1BBL, AI848817, Cd137l, CD137L, Ly63l, TNFSF9

Protein level used designations for TNFSF9

  • costimulatory molecule
  • tumor necrosis factor (ligand) superfamily, member 9
  • 4-1BB ligand
  • tumor necrosis factor ligand superfamily member 9
  • 4-1BBL
  • homolog of mouse 4-1BB-L
  • receptor 4-1BB ligand
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