TNNT3 Produits
(Fast Skeletal Troponin T (TNNT3))
Catégories
The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein\; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009].
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Catégories TNNT3 en vedette
TNNT3 Anticorps
High quality antibodies with extensive validation data.
TNNT3 Kits ELISA
Reliable ELISA kits for a wide range of species.
TNNT3 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
TNNT3 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
- (2)
N° du produit
ABIN563217
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Application
WB, ELISA, IHC, ICC, IF
Validations
- (2)
N° du produit
ABIN6257189
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
N° du produit
ABIN521034
Quantité
200 μL
Fiche technique
Fiche technique
TNNT3 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6963595
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6970896
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6970897
Quantité
96 tests
Fiche technique
Fiche technique
TNNT3 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1323292
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7401554
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
N° du produit
ABIN2720887
Quantité
20 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits TNNT3
: "Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1, and enhances skeletal muscle force in aging sedentary mice." dans: Aging cell, Vol. 15, Issue 3, pp. 488-98, (2016) (PubMed).: "Hypothyroidism and its rapid correction alter cardiac remodeling." dans: PLoS ONE, Vol. 9, Issue 10, pp. e109753, (2014) (PubMed).
: "Troponin T nuclear localization and its role in aging skeletal muscle." dans: Age (Dordrecht, Netherlands), Vol. 35, Issue 2, pp. 353-70, (2013) (PubMed).
: "Nonmyofilament-associated troponin T3 nuclear and nucleolar localization sequence and leucine zipper domain mediate muscle cell apoptosis." dans: Cytoskeleton (Hoboken, N.J.), Vol. 70, Issue 3, pp. 134-47, (2013) (PubMed).
: "Proteome dynamics during contractile and metabolic differentiation of bovine foetal muscle." dans: Animal : an international journal of animal bioscience, Vol. 3, Issue 7, pp. 980-1000, (2012) (PubMed).
: "A novel mutation in TNNT3 associated with Sheldon-Hall syndrome in a Chinese family with vertical talus." dans: European journal of medical genetics, Vol. 54, Issue 3, pp. 351-3, (2011) (PubMed).
Synonymes et noms alternatifs relatifs à TNNT3
troponin T3, fast skeletal type (TNNT3), troponin T3, skeletal, fast (Tnnt3), troponin T3, fast skeletal type S homeolog (tnnt3.S), troponin T3, fast skeletal type (Tnnt3), troponin T type 3 (skeletal, fast) (TNNT3), troponin T1, slow skeletal type (TNNT1), fTnT, Tnnt3, tnnt3a, Tnt, TNTF, TnTfProtein level used designations for TNNT3
- troponin T variant TnTx7-e16
- troponin T, fast skeletal muscle isoforms
- troponin T3, skeletal, fast
- fast skeletal muscle troponin T
- fast skeletal muscle troponin T3
- skeletal muscle fast-twitch TnT
- tnTf
- troponin T, fast skeletal muscle
- beta TnTF
- beta-TnTF
- fTnT
- troponin-T3, skeletal, fast
- troponin T fast skeletal muscle type
- fast skeletal troponin T beta-1 isoform
- skeletal troponin T alpha-1 isoform
- Fast skeletal muscle troponin T
- Troponin T, fast skeletal muscle
- fetal troponin T 1
- fetal troponin T 2
- troponin T 2f
- troponin T 2fa
- troponin T 4f
- troponin T1f
- troponin T type 1 (skeletal, slow)
- troponin T, slow skeletal muscle
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