Topoisomerase II alpha Produits
(Topoisomerase (DNA) II alpha 170kDa (TOP2A))
Catégories
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010].
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Catégories Topoisomerase II alpha en vedette
Topoisomerase II alpha Anticorps
High quality antibodies with extensive validation data.
Topoisomerase II alpha Kits ELISA
Reliable ELISA kits for a wide range of species.
Topoisomerase II alpha Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
Topoisomerase II alpha recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Mouse, Rat
Application
IHC, IF
Validations
- (12)
N° du produit
ABIN7075937
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Rat
Application
WB, ELISA, FACS, ICC
Validations
- (7)
N° du produit
ABIN7193564
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IF, IHC (p)
Validations
- (1)
- (5)
N° du produit
ABIN563224
Quantité
100 μg
Fiche technique
Fiche technique
Topoisomerase II alpha recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6970754
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Qualitative Cell ELISA
Validations
N° du produit
ABIN1380476
Quantité
2 x 96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Qualitative Cell ELISA
Validations
N° du produit
ABIN1380808
Quantité
2 x 96 tests
Fiche technique
Fiche technique
Topoisomerase II alpha recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1323347
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7013599
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN2751809
Quantité
5 applications
Fiche technique
Fiche technique
Dernières publications sur nos produits Topoisomerase II alpha
: "Type IIB DNA topoisomerase is downregulated by trastuzumab and doxorubicin to synergize cardiotoxicity." dans: Oncotarget, Vol. 9, Issue 5, pp. 6095-6108, (2018) (PubMed).: "Chromosome Scaffold is a Double-Stranded Assembly of Scaffold Proteins." dans: Scientific reports, Vol. 5, pp. 11916, (2015) (PubMed).
: "Tumour expression of bladder cancer-associated urinary proteins." dans: BJU international, Vol. 112, Issue 3, pp. 407-15, (2013) (PubMed).
: "Antibodies biotinylated using a synthetic Z-domain from protein A provide stringent in situ protein detection." dans: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 61, Issue 11, pp. 773-84, (2013) (PubMed).
: "DNA topoisomerase IIalpha is required for RNA polymerase II transcription on chromatin templates." dans: Nature, Vol. 413, Issue 6854, pp. 435-8, (2001) (PubMed).
Synonymes et noms alternatifs relatifs à Topoisomerase II alpha
DNA topoisomerase II alpha (TOP2A), DNA topoisomerase II, alpha isozyme (Bm1_08705), topoisomerase (DNA) II alpha (Top2a), DNA topoisomerase II alpha (Top2a), topoisomerase (DNA) II alpha (TOP2A), Zincin-like metalloproteases family protein (AT5G10540), DNA topoisomerase II alpha (top2a), F12B17.110, F12B17_110, fc08c07, thimet metalloendopeptidase 2, Top-2, TOP-2, TOP2, TOP2A, TP2A, wu:fc08c07Protein level used designations for Topoisomerase II alpha
- DNA gyrase
- DNA topoisomerase (ATP-hydrolyzing)
- DNA topoisomerase 2-alpha
- DNA topoisomerase II, 170 kD
- DNA topoisomerase II, alpha isozyme
- DNA Topoisomerase II alpha
- topoisomerase (DNA) 2 alpha
- DNA topoisomeraseII_alpha
- topoisomerase (DNA) II alpha
- Thimet metalloendopeptidase 2
- Zincin-like metalloproteases family protein 2
- topoisomerase 2
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