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TPCN2 Produits

(Two Pore Segment Channel 2 (TPCN2))
This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.[provided by RefSeq, Dec 2009].

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Catégories TPCN2 en vedette

TPCN2 Anticorps

High quality antibodies with extensive validation data.

TPCN2 Kits ELISA

Reliable ELISA kits for a wide range of species.

TPCN2 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

TPCN2 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
N° du produit ABIN570776
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application WB, IHC, IF
Validations
  • (3)
N° du produit ABIN7043872
Quantité 25 μL
Fiche technique Fiche technique
Reactivity Mouse
Application WB, IHC
Validations
  • (1)
N° du produit ABIN351016
Quantité 500 μg
Fiche technique Fiche technique

TPCN2 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
N° du produit ABIN6199931
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method Quantitative Competition ELISA
Validations
N° du produit ABIN6199932
Quantité 96 tests
Fiche technique Fiche technique

TPCN2 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3116758
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3125362
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Mouse, Rat
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN2751820
Quantité 5 applications
Fiche technique Fiche technique

Dernières publications sur nos produits TPCN2

Lin, Izar, Wang, Yapp, Mei, Shah, Santagata, Sorger: "Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes." dans: eLife, Vol. 7, (2019) (PubMed).

Lee, Tong, Cheng, Hung, Cheung: "Characterization of Two-Pore Channel 2 by Nuclear Membrane Electrophysiology." dans: Scientific reports, Vol. 6, pp. 20282, (2016) (PubMed).

Favia, Desideri, Gambara, DAlessio, Ruas, Esposito, Del Bufalo, Parrington, Ziparo, Palombi, Galione, Filippini: "VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 44, pp. E4706-15, (2014) (PubMed).

Arndt, Castonguay, Arlt, Meyer, Hassan, Borth, Zierler, Wennemuth, Breit, Biel, Wahl-Schott, Gudermann, Klugbauer, Boekhoff: "NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa." dans: Molecular biology of the cell, Vol. 25, Issue 6, pp. 948-64, (2014) (PubMed).

Calcraft, Ruas, Pan, Cheng, Arredouani, Hao, Tang, Rietdorf, Teboul, Chuang, Lin, Xiao, Wang, Zhu, Lin, Wyatt, Parrington, Ma, Evans, Galione, Zhu: "NAADP mobilizes calcium from acidic organelles through two-pore channels." dans: Nature, Vol. 459, Issue 7246, pp. 596-600, (2009) (PubMed).

Synonymes et noms alternatifs relatifs à TPCN2

two pore segment channel 2 (tpcn2), two pore segment channel 2 (Tpcn2), two pore segment channel 2 (TPCN2), two pore segment channel 2 L homeolog (tpcn2.L), two pore calcium channel protein 2 (LOC100444397), BC025890, D830047E22Rik, fi42c05, im:7140344, MGC115225, SHEP10, TPC2, wu:fi42c05, zgc:152898

Protein level used designations for TPCN2

  • two pore calcium channel protein 2
  • voltage-dependent calcium channel protein TPC2
  • two pore segment channel 2
  • two pore calcium channel protein 2-like
  • two-pore calcium channel protein 2
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