TWEAK Produits
(Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12))
Catégories
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene\; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010].
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Catégories TWEAK en vedette
TWEAK Anticorps
High quality antibodies with extensive validation data.
TWEAK Kits ELISA
Reliable ELISA kits for a wide range of species.
TWEAK Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
TWEAK recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC, IF
Validations
- (5)
N° du produit
ABIN6149339
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (4)
N° du produit
ABIN6265650
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
IHC
Validations
- (3)
N° du produit
ABIN7261608
Quantité
200 μL
Fiche technique
Fiche technique
TWEAK recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
N° du produit
ABIN6962633
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6970936
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6960250
Quantité
96 tests
Fiche technique
Fiche technique
TWEAK recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
N° du produit
ABIN7275763
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
HEK-293T Cells
Validations
- (2)
N° du produit
ABIN4369884
Quantité
2 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1323218
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits TWEAK
: "Serum tumor necrosis factor-like weak inducer of apoptosis levels are elevated in schizophrenia." dans: Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), (2020) (PubMed).: "The inflammatory cytokine TWEAK decreases PGC-1α expression and mitochondrial function in acute kidney injury." dans: Kidney international, Vol. 89, Issue 2, pp. 399-410, (2016) (PubMed).
: "TWEAK protects cardiomyocyte against apoptosis in a PI3K/AKT pathway dependent manner." dans: American journal of translational research, Vol. 8, Issue 9, pp. 3848-3860, (2016) (PubMed).
: "Increased serum tumor necrosis factor receptor-associated factor-6 expression in patients with non-metastatic triple-negative breast cancer." dans: Oncology letters, Vol. 9, Issue 6, pp. 2819-2824, (2015) (PubMed).
: "Therapeutic targeting of TWEAK/Fnl4 in cancer: exploiting the intrinsic tumor cell killing capacity of the pathway." dans: Results and problems in cell differentiation, Vol. 49, pp. 145-60, (2010) (PubMed).
: "Fibroblast growth factor-inducible 14 (Fn14) is expressed in the lower genital tract and may play a role in amplifying inflammation during infection." dans: Journal of reproductive immunology, Vol. 84, Issue 1, pp. 16-23, (2010) (PubMed).
: "Expression profiles of novel cell surface molecules on B-cell subsets and plasma cells as analyzed by flow cytometry." dans: Immunology letters, Vol. 134, Issue 2, pp. 113-21, (2010) (PubMed).
: "TWEAK/Fn14 interaction stimulates human bronchial epithelial cells to produce IL-8 and GM-CSF." dans: Biochemical and biophysical research communications, Vol. 318, Issue 2, pp. 422-7, (2004) (PubMed).
: "The apoptotic ligands TRAIL, TWEAK, and Fas ligand mediate monocyte death induced by autologous lupus T cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 10, pp. 6020-9, (2002) (PubMed).
: "Involvement of TWEAK in interferon gamma-stimulated monocyte cytotoxicity." dans: The Journal of experimental medicine, Vol. 192, Issue 9, pp. 1373-80, (2000) (PubMed).
Synonymes et noms alternatifs relatifs à TWEAK
TNF superfamily member 12 (TNFSF12), tumor necrosis factor (ligand) superfamily, member 12 (TNFSF12), tumor necrosis factor (ligand) superfamily, member 12 (Tnfsf12), TNF superfamily member 12 (Tnfsf12), APO3L, Apo3l, Dr3l, DR3LG, Dr3lg, TWEAK, TweakProtein level used designations for TWEAK
- APO3 ligand
- APO3/DR3 ligand
- TNF-related WEAK inducer of apoptosis
- tumor necrosis factor ligand superfamily member 12
- tumor necrosis factor superfamily member 12
- TNF-related weak inducer of apoptosis
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