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TXK Produits

(TXK tyrosine Kinase (TXK))
Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T- cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskekleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell- specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr- 201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.

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Catégories TXK en vedette

TXK Anticorps

High quality antibodies with extensive validation data.

TXK Kits ELISA

Reliable ELISA kits for a wide range of species.

TXK Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

TXK recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application ELISA, WB, IHC, IF
Validations
  • (4)
N° du produit ABIN7174076
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC (p)
Validations
  • (3)
N° du produit ABIN392114
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human
Application ELISA, WB, IF
Validations
  • (3)
N° du produit ABIN521176
Quantité 100 μg
Fiche technique Fiche technique

TXK recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6971009
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
N° du produit ABIN4886333
Quantité 96 tests
Fiche technique Fiche technique

TXK recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1324214
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Rat
Source Insect Cells
Validations
N° du produit ABIN5509229
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Insect Cells
Validations
N° du produit ABIN5509188
Quantité 10 μg
Fiche technique Fiche technique

Dernières publications sur nos produits TXK

Suzuki, Nara, Suzuki: "Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease." dans: Clinical medicine & research, Vol. 4, Issue 2, pp. 147-51, (2006) (PubMed).

Takeba, Nagafuchi, Takeno, Kashiwakura, Suzuki: "Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 5, pp. 2365-70, (2002) (PubMed).

Synonymes et noms alternatifs relatifs à TXK

TXK tyrosine kinase (TXK), TXK tyrosine kinase (Txk), tyrosine-protein kinase TXK (LOC100544958), A130089B16Rik, BTKL, Btkl, PSCTK5, PTK4, RLK, Rlk, TKL

Protein level used designations for TXK

  • PTK4 protein tyrosine kinase 4
  • protein-tyrosine kinase 4
  • resting lymphocyte kinase
  • tyrosine kinase
  • tyrosine-protein kinase TXK
  • PTK-RL-18
  • TXK tyrosine kinase
  • tyrosine-protein kinase TXK-like
  • LOW QUALITY PROTEIN: tyrosine-protein kinase TXK
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