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TYK2 Produits

(Tyrosine Kinase 2 (TYK2))

Catégories

This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008].

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Catégories TYK2 en vedette

TYK2 Anticorps

High quality antibodies with extensive validation data.

TYK2 Kits ELISA

Reliable ELISA kits for a wide range of species.

TYK2 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

TYK2 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, IF, IHC (p), IP
Validations
  • (7)
N° du produit ABIN563303
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC (p)
Validations
  • (6)
N° du produit ABIN521186
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC, IF
Validations
  • (6)
N° du produit ABIN3022988
Quantité 100 μL
Fiche technique Fiche technique

TYK2 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
  • (3)
N° du produit ABIN1981732
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6971021
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6960329
Quantité 96 tests
Fiche technique Fiche technique

TYK2 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1324253
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Insect Cells
Validations
N° du produit ABIN5509189
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7394390
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits TYK2

Forsström, Axnäs, Stengele, Bühler, Albert, Richmond, Hu, Nilsson, Hudson, Rockberg, Uhlen: "Proteome-wide epitope mapping of antibodies using ultra-dense peptide arrays." dans: Molecular & cellular proteomics : MCP, Vol. 13, Issue 6, pp. 1585-97, (2014) (PubMed).

Sanda, Tyner, Gutierrez, Ngo, Glover, Chang, Yost, Ma, Fleischman, Zhou, Yang, Kleppe, Ahn, Tatarek, Kelliher, Neuberg, Levine, Moriggl, Müller, Gray, Jamieson, Weng, Staudt, Druker, Look: "TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia." dans: Cancer discovery, Vol. 3, Issue 5, pp. 564-77, (2013) (PubMed).

Shaw, Freeman, Scott, Fox, Bzik, Belkaid, Yap: "Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 12, pp. 7263-71, (2006) (PubMed).

Zheng, Hu, Quinn, Wang: "Phosphotyrosine proteomic study of interferon alpha signaling pathway using a combination of immunoprecipitation and immobilized metal affinity chromatography." dans: Molecular & cellular proteomics : MCP, Vol. 4, Issue 6, pp. 721-30, (2005) (PubMed).

Stoiber, Kovacic, Schuster, Schellack, Karaghiosoff, Kreibich, Weisz, Artwohl, Kleine, Muller, Baumgartner-Parzer, Ghysdael, Freissmuth, Sexl: "TYK2 is a key regulator of the surveillance of B lymphoid tumors." dans: The Journal of clinical investigation, Vol. 114, Issue 11, pp. 1650-8, (2004) (PubMed).

Seto, Nakajima, Suto, Shimoda, Saito, Nakayama, Iwamoto: "Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 2, pp. 1077-83, (2003) (PubMed).

Ragimbeau, Dondi, Alcover, Eid, Uzé, Pellegrini: "The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression." dans: The EMBO journal, Vol. 22, Issue 3, pp. 537-47, (2003) (PubMed).

Kiian, Tkachuk, Haller, Dumler: "Urokinase-induced migration of human vascular smooth muscle cells requires coupling of the small GTPases RhoA and Rac1 to the Tyk2/PI3-K signalling pathway." dans: Thrombosis and haemostasis, Vol. 89, Issue 5, pp. 904-14, (2003) (PubMed).

Lukashova, Chen, Duhé, Rola-Pleszczynski, Stanková: "Janus kinase 2 activation by the platelet-activating factor receptor (PAFR): roles of Tyk2 and PAFR C terminus." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 7, pp. 3794-800, (2003) (PubMed).

Blesofsky, Mowen, Arduini, Baker, Murphy, Bowtell, David: "Regulation of STAT protein synthesis by c-Cbl." dans: Oncogene, Vol. 20, Issue 50, pp. 7326-33, (2001) (PubMed).

Synonymes et noms alternatifs relatifs à TYK2

tyrosine kinase 2 (TYK2), tyrosine kinase 2 (Tyk2), JTK1

Protein level used designations for TYK2

  • non-receptor tyrosine-protein kinase TYK2
  • tyrosine kinase TYK2
  • non-receptor tyrosine kinase Tyk2
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