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TYROBP Produits

(TYRO Protein tyrosine Kinase Binding Protein (TYROBP))
This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010].

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Catégories TYROBP en vedette

TYROBP Anticorps

High quality antibodies with extensive validation data.

TYROBP Kits ELISA

Reliable ELISA kits for a wide range of species.

TYROBP Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

TYROBP recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, FACS, IHC (p)
Validations
  • (3)
N° du produit ABIN653819
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Mouse, Rat
Application IHC
Validations
  • (2)
N° du produit ABIN7261337
Quantité 200 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC, ELISA
Validations
  • (2)
N° du produit ABIN6265826
Quantité 100 μL
Fiche technique Fiche technique

TYROBP recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6971010
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6960320
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method Quantitative Competition ELISA
Validations
N° du produit ABIN5593698
Quantité 96 tests
Fiche technique Fiche technique

TYROBP recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1324265
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1324267
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7414999
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits TYROBP

Russo, Fiore, van Vreden, Bailey, Santarelli, McGuire, Fazekas de St Groth, Austin: "Expansion and activation of distinct central memory T lymphocyte subsets in complex regional pain syndrome." dans: Journal of neuroinflammation, Vol. 16, Issue 1, pp. 63, (2019) (PubMed).

Tecle, Reynoso, Wang, Gagneux: "The female reproductive tract contains multiple innate sialic acid-binding immunoglobulin-like lectins (Siglecs) that facilitate sperm survival." dans: The Journal of biological chemistry, Vol. 294, Issue 31, pp. 11910-11919, (2019) (PubMed).

Chan, White, Winn, Cimpean, Replogle, Glick, Cuerdon, Ryan, Johnson, Schneider, Bennett, Chibnik, Sperling, Bradshaw, De Jager: "CD33 modulates TREM2: convergence of Alzheimer loci." dans: Nature neuroscience, Vol. 18, Issue 11, pp. 1556-8, (2016) (PubMed).

Preusse, Goebel, Pehl, Rinnenthal, Kley, Allenbach, Heppner, Vorgerd, Authier, Gherardi, Stenzel: "Th2-M2 immunity in lesions of muscular sarcoidosis and macrophagic myofasciitis." dans: Neuropathology and applied neurobiology, Vol. 41, Issue 7, pp. 952-63, (2015) (PubMed).

Mulrooney, Posch, Hurley: "DAP12 impacts trafficking and surface stability of killer immunoglobulin-like receptors on natural killer cells." dans: Journal of leukocyte biology, Vol. 94, Issue 2, pp. 301-13, (2013) (PubMed).

Lanier, Bakker: "The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function." dans: Immunology today, Vol. 21, Issue 12, pp. 611-4, (2001) (PubMed).

Paloneva, Kestilä, Wu, Salminen, Böhling, Ruotsalainen, Hakola, Bakker, Phillips, Pekkarinen, Lanier, Timonen, Peltonen: "Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts." dans: Nature genetics, Vol. 25, Issue 3, pp. 357-61, (2000) (PubMed).

Tomasello, Desmoulins, Chemin, Guia, Cremer, Ortaldo, Love, Kaiserlian, Vivier: "Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice." dans: Immunity, Vol. 13, Issue 3, pp. 355-64, (2000) (PubMed).

Synonymes et noms alternatifs relatifs à TYROBP

TYRO protein tyrosine kinase binding protein (TYROBP), TYRO protein tyrosine kinase binding protein (tyrobp), Tyro protein tyrosine kinase binding protein (Tyrobp), TYRO protein tyrosine kinase binding protein (Tyrobp), DAP12, dap12, Karap, KARAP, Ly83, PLOSL, TYROBP, tyrpbp

Protein level used designations for TYROBP

  • TYRO protein tyrosine kinase-binding protein
  • TYRO protein tyrosine kinase binding protein
  • DAP12 protein
  • dap12
  • DAP12
  • DNAX-activation protein 12
  • killer cell activating receptor-associated protein
  • KAR-associated protein
  • killer activating receptor associated protein
  • killer-activating receptor-associated protein
  • killer cell activating receptor associated protein
  • immunoreceptor DAP12
  • tyrosine kinase binding protein
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