This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase modification, endocytosis, and regulation of other cell signaling pathways. [provided by RefSeq, Aug 2010].
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Li, Chan, Yu, Bei, Chen, Zhou, Cheng, Chen, Ziegler, Rowe, Das, Xiao: "miR-29b contributes to multiple types of muscle atrophy." dans: Nature communications, Vol. 8, pp. 15201, (2018) (PubMed).
Wang, Hu, Xiao, Wang, Liu, Xu, Shi, Jiang, Huang, Li, Liu, Qing: "Stabilization of Notch1 by the Hsp90 Chaperone Is Crucial for T-Cell Leukemogenesis." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 23, Issue 14, pp. 3834-3846, (2018) (PubMed).
Xiao, Yue, Su, Ren, Jiang, Li, Hu, Du, Liu, Qing: "Polo-like Kinase-1 Regulates Myc Stabilization and Activates a Feedforward Circuit Promoting Tumor Cell Survival." dans: Molecular cell, Vol. 64, Issue 3, pp. 493-506, (2017) (PubMed).
Synonymes et noms alternatifs relatifs à UBC
ubiquitin C (UBC), ubiquitin C (Ubc), 2700054O04Rik, AI194771, HMG20, Rps27a, TI-225, Uba52, Ubb