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UGT1A1 Produits

(UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1))
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome. [provided by RefSeq, Jul 2008].

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Catégories UGT1A1 en vedette

UGT1A1 Anticorps

High quality antibodies with extensive validation data.

UGT1A1 Kits ELISA

Reliable ELISA kits for a wide range of species.

UGT1A1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

UGT1A1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IHC, IF
Validations
  • (1)
  • (6)
N° du produit ABIN6149895
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application IF
Validations
  • (4)
N° du produit ABIN7262012
Quantité 200 μL
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC
Validations
  • (5)
N° du produit ABIN5693290
Quantité 100 μg
Fiche technique Fiche technique

UGT1A1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
N° du produit ABIN6960358
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
N° du produit ABIN6975305
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (2)
  • (1)
N° du produit ABIN6960359
Quantité 96 tests
Fiche technique Fiche technique

UGT1A1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1324569
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7408798
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7404989
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits UGT1A1

Lv, Feng, Ai, Hou, Wang, Zou, Cheng, Ge, Cui, Yang: "A Practical and High-Affinity Fluorescent Probe for Uridine Diphosphate Glucuronosyltransferase 1A1: A Good Surrogate for Bilirubin." dans: Journal of medicinal chemistry, Vol. 60, Issue 23, pp. 9664-9675, (2017) (PubMed).

Kim, Gallaher, Chen, Gallaher, Yao, Trudo: "Phenethyl isothiocyanate and indole-3-carbinol from cruciferous vegetables, but not furanocoumarins from apiaceous vegetables, reduced PhIP-induced DNA adducts in Wistar rats." dans: Molecular nutrition & food research, Vol. 60, Issue 9, pp. 1956-66, (2016) (PubMed).

Kim, Gallaher, Chen, Yao, Trudo: "Apiaceous vegetable consumption decreases PhIP-induced DNA adducts and increases methylated PhIP metabolites in the urine metabolome in rats." dans: The Journal of nutrition, Vol. 145, Issue 3, pp. 442-51, (2015) (PubMed).

Yang, He, Zhou: "Fenofibrate pre-treatment suppressed inflammation by activating phosphoinositide 3 kinase/protein kinase B (PI3K/Akt) signaling in renal ischemia-reperfusion injury." dans: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, Vol. 35, Issue 1, pp. 58-63, (2015) (PubMed).

Ding, Zhang, Zhan, Yang, Wang: "Danning tablets attenuates ?-naphthylisothiocyanate-induced cholestasis by modulating the expression of transporters and metabolic enzymes." dans: BMC complementary and alternative medicine, Vol. 14, pp. 249, (2014) (PubMed).

Synonymes et noms alternatifs relatifs à UGT1A1

UDP glucuronosyltransferase family 1 member A1 (UGT1A1), UDP glucuronosyltransferase 1 family, polypeptide A1 (Ugt1a1), UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1), UDP-glucuronosyltransferase 1-1 (LOC100065342), UDP-glucuronosyltransferase (LOC100125517), UDP-glucuronosyltransferase 1-1 (LOC100229734), UDP-glucuronosyltransferase 1-6 (LOC100405984), UDP-glucuronosyltransferase 1-1 (LOC100511479), UDP glucuronosyltransferase family 1 member A1 (Ugt1a1), UDP glucuronosyltransferase 1 family polypeptide a1 (ugt1a1), BILIQTL1, GNT1, Gnt1, HUG-BR1, UDPGT, Udpgt, Udpgt-1a, UDPGT 1-1, UGT1, Ugt1, UGT1A, UGT1A01, UgtBr1, zgc:123097

Protein level used designations for UGT1A1

  • UDP glycosyltransferase 1 family, polypeptide A1
  • UDP-glucuronosyltransferase 1-1
  • UDP-glucuronosyltransferase 1-A
  • UDP-glucuronosyltransferase 1A1
  • UGT-1A
  • UGT1*1
  • UGT1-01
  • UGT1.1
  • bilirubin UDP-glucuronosyltransferase 1-1
  • bilirubin UDP-glucuronosyltransferase isozyme 1
  • bilirubin-specific UDPGT isozyme 1
  • UDP-glucuronosyltransferase 1 family, member 1
  • UDP-glucuronosyltransferase 1 family, polypeptide A1
  • UDPGT
  • UDP glucuronosyltransferase 1 family, polypeptide A1
  • uridine diphosphate glucuronosyltransferase 1A1
  • UDP-glucuronosyltransferase UGT1A01
  • UDP glucuronosyltransferase 1 family polypeptide A1
  • UDP glycosyl transferase 1A1
  • UDP-glucuronosyltransferase 1-1-like
  • B1
  • UDP-glucuronosyltransferase 1 family member 1
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