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UIMC1 Produits

(Ubiquitin Interaction Motif Containing 1 (UIMC1))

Catégories

Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B\; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly Act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1 (By similarity).

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Catégories UIMC1 en vedette

UIMC1 Anticorps

High quality antibodies with extensive validation data.

UIMC1 Kits ELISA

Reliable ELISA kits for a wide range of species.

UIMC1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

UIMC1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, FACS
Validations
  • (1)
  • (2)
N° du produit ABIN1944736
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (2)
N° du produit ABIN7145750
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, IP
Validations
  • (2)
N° du produit ABIN526885
Quantité 100 μL
Fiche technique Fiche technique

UIMC1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method
Validations
N° du produit ABIN1124110
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method
Validations
N° du produit ABIN1124111
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method
Validations
N° du produit ABIN1124113
Quantité 96 tests
Fiche technique Fiche technique

UIMC1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1324614
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3096257
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Rat
Source Yeast
Validations
N° du produit ABIN1634738
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits UIMC1

Baranes-Bachar, Levy-Barda, Oehler, Reid, Soria-Bretones, Voss, Chung, Park, Liu, Yoon, Li, Dellaire, Misteli, Huertas, Rothenberg, Ramadan, Ziv, Shiloh: "The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair." dans: Molecular cell, Vol. 69, Issue 5, pp. 866-878.e7, (2019) (PubMed).

Bodo, Campagne, Thin, Higginson, Vargas, Hua, Fuller, Ackerstaff, Russell, Zhang, Klingler, Cho, Kaag, Mazaheri, Rimner, Manova-Todorova, Epel, Zatcky, Cleary, Rao, Yamada, Zelefsky, Halpern et al.: "Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury. ..." dans: The Journal of clinical investigation, Vol. 129, Issue 2, pp. 786-801, (2019) (PubMed).

Watanabe, Iimori, Chan, Hara, Kitao, Maehara: "MDC1 methylation mediated by lysine methyltransferases EHMT1 and EHMT2 regulates active ATM accumulation flanking DNA damage sites." dans: Scientific reports, Vol. 8, Issue 1, pp. 10888, (2018) (PubMed).

Yasuhara, Kato, Hagiwara, Shiotani, Yamauchi, Nakada, Shibata, Miyagawa: "Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair." dans: Cell, Vol. 175, Issue 2, pp. 558-570.e11, (2018) (PubMed).

Ha, Ma, Lin, Tang, Lian, Zhao, Li, Zhen, Pei, Han, Malumbres, Jin, Chen, Zhao, Zhu, Zhang: "The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites." dans: Nature communications, Vol. 8, pp. 15751, (2017) (PubMed).

Renaud, Barascu, Rosselli: "Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells." dans: Nucleic acids research, Vol. 44, Issue 2, pp. 648-56, (2016) (PubMed).

Lin, Ratner, Whicker, Lee, Sartorelli: "Triapine disrupts CtIP-mediated homologous recombination repair and sensitizes ovarian cancer cells to PARP and topoisomerase inhibitors." dans: Molecular cancer research : MCR, Vol. 12, Issue 3, pp. 381-93, (2014) (PubMed).

Kato, Nakajima, Ui, Muto-Terao, Ogiwara, Nakada: "Fine-tuning of DNA damage-dependent ubiquitination by OTUB2 supports the DNA repair pathway choice." dans: Molecular cell, Vol. 53, Issue 4, pp. 617-30, (2014) (PubMed).

Hu, Paul, Wang: "Rap80 protein recruitment to DNA double-strand breaks requires binding to both small ubiquitin-like modifier (SUMO) and ubiquitin conjugates." dans: The Journal of biological chemistry, Vol. 287, Issue 30, pp. 25510-9, (2012) (PubMed).

Hu, Kim, Castillo, Huang, Liu, Wang: "NBA1/MERIT40 and BRE interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36-containing complexes." dans: The Journal of biological chemistry, Vol. 286, Issue 13, pp. 11734-45, (2011) (PubMed).

Synonymes et noms alternatifs relatifs à UIMC1

ubiquitin interaction motif containing 1 (UIMC1), ubiquitin interaction motif containing 1 (Uimc1), 9430016E08Rik, D330018D10Rik, D630032M02Rik, RAP80, RGD1307009, RIP110, Rxrip110, UIMC1, X2HRIP110

Protein level used designations for UIMC1

  • ubiquitin interaction motif containing 1
  • BRCA1-A complex subunit RAP80-like
  • BRCA1-A complex subunit RAP80
  • receptor-associated protein 80
  • ubiquitin interaction motif-containing protein 1
  • receptor associated protein 80
  • retinoid X receptor-interacting protein 110
  • retinoid x receptor interacting protein
  • retinoid X receptor interacting protein 110
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