UPF3B Produits
(UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B))
Catégories
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Catégories UPF3B en vedette
UPF3B Anticorps
High quality antibodies with extensive validation data.
UPF3B Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
UPF3B recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p)
Validations
- (1)
- (4)
N° du produit
ABIN3043956
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (3)
N° du produit
ABIN7167644
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Cow, Human
Application
WB, IHC, IHC (p)
Validations
- (2)
N° du produit
ABIN203166
Quantité
100 μL
Fiche technique
Fiche technique
UPF3B recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6234778
Quantité
96 tests
Fiche technique
Fiche technique
UPF3B recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
N° du produit
ABIN2735037
Quantité
20 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits UPF3B
: "Antisense suppression of the nonsense mediated decay factor Upf3b as a potential treatment for diseases caused by nonsense mutations." dans: Genome biology, Vol. 19, Issue 1, pp. 4, (2018) (PubMed).: "RNA sequencing of synaptic and cytoplasmic Upf1-bound transcripts supports contribution of nonsense-mediated decay to epileptogenesis." dans: Scientific reports, Vol. 7, pp. 41517, (2017) (PubMed).
Synonymes et noms alternatifs relatifs à UPF3B
UPF3B, regulator of nonsense mediated mRNA decay (UPF3B), UPF3 regulator of nonsense transcripts homolog B (yeast) (Upf3b), UPF3B, regulator of nonsense mediated mRNA decay (Upf3b), 5730594O13Rik, AI317193, AW541158, HUPF3B, MRXS14, RENT3B, RGD1560264, UPF3XProtein level used designations for UPF3B
- hUpf3p-X
- nonsense mRNA reducing factor 3B
- regulator of nonsense transcripts 3B
- up-frameshift suppressor 3 homolog B
- up-frameshift suppressor 3 homolog on chromosome X
- hUPF3B
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