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Uromodulin Produits

(Uromodulin (UMOD))

Catégories

This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq, Jul 2008].

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Catégories Uromodulin en vedette

Uromodulin Anticorps

High quality antibodies with extensive validation data.

Uromodulin Kits ELISA

Reliable ELISA kits for a wide range of species.

Uromodulin Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

Uromodulin recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC (p), IHC (fro), FACS, IF (cc), IF (p)
Validations
  • (2)
  • (4)
N° du produit ABIN678473
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IP
Validations
  • (2)
  • (4)
N° du produit ABIN521253
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Dog
Application WB, IHC, IP, ICC
Validations
  • (4)
N° du produit ABIN7437641
Quantité 100 μL
Fiche technique Fiche technique

Uromodulin recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
N° du produit ABIN6960396
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (2)
  • (1)
N° du produit ABIN6960397
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6971085
Quantité 96 tests
Fiche technique Fiche technique

Uromodulin recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1324635
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1324633
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7505005
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits Uromodulin

Wróbel, Zapała, Zapała, Piecha, Radziszewski: "The effect of O-1602, a GPR55 agonist, on the cyclophosphamide-induced rat hemorrhagic cystitis." dans: European journal of pharmacology, Vol. 882, pp. 173321, (2020) (PubMed).

Luciani, Schumann, Berquez, Chen, Nieri, Failli, Debaix, Festa, Tokonami, Raimondi, Cremonesi, Carrella, Forny, Kölker, Diomedi Camassei, Diaz, Moraes, Di Bernardo, Baumgartner, Devuyst: "Impaired mitophagy links mitochondrial disease to epithelial stress in methylmalonyl-CoA mutase deficiency." dans: Nature communications, Vol. 11, Issue 1, pp. 970, (2020) (PubMed).

Cho, Song, Oh, Kim, Ko, Lee, Jo: "Fate of Neutrophils during the Recovery Phase of Ischemia/Reperfusion Induced Acute Kidney Injury." dans: Journal of Korean medical science, Vol. 32, Issue 10, pp. 1616-1625, (2018) (PubMed).

Kim, Ko, Lee, Kim, Jo, Cho: "Blocking junctional adhesion molecule C promotes the recovery of cisplatin-induced acute kidney injury." dans: The Korean journal of internal medicine, Vol. 32, Issue 6, pp. 1053-1061, (2018) (PubMed).

Brunati, Perucca, Han, Cattaneo, Consolato, Andolfo, Schaeffer, Olinger, Peng, Santambrogio, Perrier, Li, Bokhove, Bachi, Hummler, Devuyst, Wu, Jovine, Rampoldi: "The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin." dans: eLife, Vol. 4, pp. e08887, (2016) (PubMed).

Cassidy, Slyne, OKelly, Traynor, Conlon, Johnston, Slattery, Ryan, McMorrow: "Urinary biomarkers of chronic allograft nephropathy." dans: Proteomics. Clinical applications, Vol. 9, Issue 5-6, pp. 574-85, (2015) (PubMed).

Dobrek, Kaszuba-Zwoińska, Skowron, Baranowska, Thor: "Urine uromodulin estimation in partial bladder outlet obstruction and cyclophosphamide-induced haemorrhagic cystitis models in rats." dans: Postȩpy higieny i medycyny doświadczalnej (Online), Vol. 68, pp. 1184-92, (2015) (PubMed).

Larkin, Zhang, Godfrey, Molostvov, Zehnder, Rabbani, Thornalley: "Glucose-induced down regulation of thiamine transporters in the kidney proximal tubular epithelium produces thiamine insufficiency in diabetes." dans: PLoS ONE, Vol. 7, Issue 12, pp. e53175, (2013) (PubMed).

Jou, Tsai, Fang, Chen, Chen, Huang, Li, Shen: "Mass spectrometric study of stone matrix proteins of human bladder stones." dans: Urology, Vol. 82, Issue 2, pp. 295-300, (2013) (PubMed).

Jou, Fang, Chen, Chen, Cheng, Shen, Liao, Tsai: "Proteomic study of renal uric acid stone." dans: Urology, Vol. 80, Issue 2, pp. 260-6, (2012) (PubMed).

Synonymes et noms alternatifs relatifs à Uromodulin

uromodulin (UMOD), uromodulin (Umod), ADMCKD2, FJHN, HNFJ, HNFJ1, MCKD2, THGP, THP, urehr4

Protein level used designations for Uromodulin

  • uromodulin
  • Tamm-Horsfall urinary glycoprotein
  • uromucoid
  • THP
  • tamm-Horsfall urinary glycoprotein
  • uromodulin (uromucoid, Tamm-Horsfall glycoprotein)
  • Urmodulin (Tamm-Horsfall protein)
  • uromucoid, human : Tamm-Horsfall glycoprotein
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