USP2 Produits
(Ubiquitin Specific Peptidase 2 (USP2))
Catégories
This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011].
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Catégories USP2 en vedette
USP2 Anticorps
High quality antibodies with extensive validation data.
USP2 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
USP2 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC (p)
Validations
- (12)
- (4)
N° du produit
ABIN388879
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human, Rat
Application
WB, IHC (p)
Validations
- (4)
- (4)
N° du produit
ABIN388877
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
N° du produit
ABIN7174279
Quantité
100 μL
Fiche technique
Fiche technique
USP2 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6232795
Quantité
96 tests
Fiche technique
Fiche technique
USP2 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7420525
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7420528
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3096154
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits USP2
: "Ubiquitin-Specific Protease 2 Modulates the Lipopolysaccharide-Elicited Expression of Proinflammatory Cytokines in Macrophage-like HL-60 Cells." dans: Mediators of inflammation, Vol. 2017, pp. 6909415, (2018) (PubMed).: "Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus." dans: PLoS pathogens, Vol. 12, Issue 7, pp. e1005764, (2017) (PubMed).
: "Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models." dans: The Journal of biological chemistry, Vol. 291, Issue 47, pp. 24628-24640, (2017) (PubMed).
: "Overexpression of ubiquitin-specific protease 2a (USP2a) and nuclear factor erythroid 2-related factor 2 (Nrf2) in human gliomas." dans: Journal of the neurological sciences, Vol. 363, pp. 249-52, (2016) (PubMed).
: "Ubiquitin-specific protease 2b negatively regulates IFN-? production and antiviral activity by targeting TANK-binding kinase 1." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 193, Issue 5, pp. 2230-7, (2014) (PubMed).
: "Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 27, Issue 12, pp. 4940-53, (2013) (PubMed).
: "USP2a protein deubiquitinates and stabilizes the circadian protein CRY1 in response to inflammatory signals." dans: The Journal of biological chemistry, Vol. 287, Issue 30, pp. 25280-91, (2012) (PubMed).
: "Ubiquitination-deubiquitination balance dictates ligand-stimulated PTHR sorting." dans: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 26, Issue 12, pp. 2923-34, (2011) (PubMed).
: "Mice lacking the USP2 deubiquitinating enzyme have severe male subfertility associated with defects in fertilization and sperm motility." dans: Biology of reproduction, Vol. 85, Issue 3, pp. 594-604, (2011) (PubMed).
: "Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC)-ubiquitylating enzyme Nedd4-2." dans: American journal of physiology. Renal physiology, Vol. 301, Issue 1, pp. F189-96, (2011) (PubMed).
Synonymes et noms alternatifs relatifs à USP2
ubiquitin specific peptidase 2 (USP2), ubiquitin specific peptidase 2 (Usp2), ubiquitin specific peptidase 2a (usp2a), B930035K21Rik, UBP-t, UBP41, Ubp41, UBP46, ubp52, ubp66, USP9, zgc:92134Protein level used designations for USP2
- 41 kDa ubiquitin-specific protease
- deubiquitinating enzyme 2
- ubiquitin carboxyl-terminal hydrolase 2
- ubiquitin specific protease 12
- ubiquitin specific protease 9
- ubiquitin thioesterase 2
- ubiquitin-specific-processing protease 2
- ubiquitin specific protease 2
- ubiquitin thiolesterase 2
- ubiquitin-specific-processing protease testis
- family of cysteine protease
- ubiquitin specific protease 41
- ubiquitin specific protease 46
- ubiquitin specific protease 52
- ubiquitin specific protease 66
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