VHL Produits
(Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL))
Catégories
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
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Catégories VHL en vedette
VHL Anticorps
High quality antibodies with extensive validation data.
VHL Kits ELISA
Reliable ELISA kits for a wide range of species.
VHL Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
VHL recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IF, IHC (p), IP, ICC
Validations
- (1)
- (8)
N° du produit
ABIN2854928
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, IF
Validations
- (3)
- (6)
N° du produit
ABIN3020968
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Application
WB, FACS, IF, IHC (p)
Validations
- (7)
N° du produit
ABIN390462
Quantité
200 μL
Fiche technique
Fiche technique
VHL recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6971170
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6960511
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN5518585
Quantité
96 tests
Fiche technique
Fiche technique
VHL recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
N° du produit
ABIN1325000
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN2132533
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7424887
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits VHL
: "Protective effect of salidroside against bone loss via hypoxia-inducible factor-1α pathway-induced angiogenesis." dans: Scientific reports, Vol. 6, pp. 32131, (2018) (PubMed).: "VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2." dans: Nature communications, Vol. 8, pp. 15337, (2018) (PubMed).
: "Salidroside accelerates fracture healing through cell-autonomous and non-autonomous effects on osteoblasts." dans: Cell and tissue research, Vol. 367, Issue 2, pp. 197-211, (2017) (PubMed).
: "Forkhead Transcription Factor 3a (FOXO3a) Modulates Hypoxia Signaling via Up-regulation of the von Hippel-Lindau Gene (VHL)." dans: The Journal of biological chemistry, Vol. 291, Issue 49, pp. 25692-25705, (2017) (PubMed).
: "An ID2-dependent mechanism for VHL inactivation in cancer." dans: Nature, Vol. 529, Issue 7585, pp. 172-7, (2016) (PubMed).
: "WSB1 promotes tumor metastasis by inducing pVHL degradation." dans: Genes & development, Vol. 29, Issue 21, pp. 2244-57, (2015) (PubMed).
: "Jumonji Domain Containing Protein 6: A Novel Oxygen Sensor in the Human Placenta." dans: Endocrinology, Vol. 156, Issue 8, pp. 3012-25, (2015) (PubMed).
: "HIF-1α disturbs osteoblasts and osteoclasts coupling in bone remodeling by up-regulating OPG expression." dans: In vitro cellular & developmental biology. Animal, Vol. 51, Issue 8, pp. 808-14, (2015) (PubMed).
: "Oncotropic H-1 parvovirus infection degrades HIF-1α protein in human pancreatic cancer cells independently of VHL and RACK1." dans: International journal of oncology, Vol. 46, Issue 5, pp. 2076-82, (2015) (PubMed).
: "pVHL Negatively Regulates Antiviral Signaling by Targeting MAVS for Proteasomal Degradation." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 4, pp. 1782-90, (2015) (PubMed).
Synonymes et noms alternatifs relatifs à VHL
von Hippel-Lindau tumor suppressor (VHL), von Hippel-Lindau (Vhl), von Hippel-Lindau tumor suppressor (vhl), von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase (VHL), von Hippel-Lindau disease tumor suppressor (CpipJ_CPIJ009992), von Hippel-Lindau tumor suppressor (Vhl), BcDNA:RH61560, CG13221, d-VHL, d-vhl, Dmel\\CG13221, dmVHL, DVhl, Dvhl, dVHL, HRCA1, hrca1, pVHL, RCA1, rca1, VHL, vhl, VHL1, vhl1, Vhlh, zgc:158722Protein level used designations for VHL
- elongin binding protein
- protein G7
- von Hippel-Lindau disease tumor suppressor
- CG13221-PA
- CG13221-PB
- Vhl-PA
- Vhl-PB
- von hippel lindau
- von hippel lindau protein
- pVHL
- von Hippel-Lindau tumor suppressor
- von Hippel-Lindau syndrome homolog
- von Hippel-Lindau syndrome protein homolog
- Von Hippel-Lindau disease tumor suppressor
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