WISP1 Produits
(WNT1 Inducible Signaling Pathway Protein 1 (WISP1))
Catégories
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011].
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Catégories WISP1 en vedette
WISP1 Anticorps
High quality antibodies with extensive validation data.
WISP1 Kits ELISA
Reliable ELISA kits for a wide range of species.
WISP1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
WISP1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IF, FACS
Validations
- (7)
N° du produit
ABIN238610
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (5)
N° du produit
ABIN7436372
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, ELISA, IF
Validations
- (4)
N° du produit
ABIN7175846
Quantité
100 μg
Fiche technique
Fiche technique
WISP1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
N° du produit
ABIN6962685
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6960559
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6960558
Quantité
96 tests
Fiche technique
Fiche technique
WISP1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (2)
N° du produit
ABIN7275850
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1325341
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN935909
Quantité
20 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits WISP1
: "Tao-Hong-Si-Wu Decoction promotes angiogenesis after cerebral ischaemia in rats via platelet microparticles." dans: Chinese journal of natural medicines, Vol. 18, Issue 8, pp. 620-627, (2020) (PubMed).: "Based on HIF-1α/Wnt/β-Catenin Pathway to Explore the Effect of Qingshen Granules on Chronic Renal Failure Patients: A Randomized Controlled Trial." dans: Evidence-based complementary and alternative medicine : eCAM, Vol. 2019, pp. 7656105, (2019) (PubMed).
: "Resveratrol Attenuates Hyperoxia-induced Oxidative Stress, Inflammation and Fibrosis and Suppresses Wnt/?-catenin Signaling in Lungs of Neonatal Rats." dans: Clinical and experimental pharmacology & physiology, (2015) (PubMed).
: "WISP-2 in human gastric cancer and its potential metastatic suppressor role in gastric cancer cells mediated by JNK and PLC-? pathways." dans: British journal of cancer, Vol. 113, Issue 6, pp. 921-33, (2015) (PubMed).
: "miR-92a regulates TGF-β1-induced WISP1 expression in pulmonary fibrosis." dans: The international journal of biochemistry & cell biology, Vol. 53, pp. 432-41, (2014) (PubMed).
: "WISP1, a pro-mitogenic, pro-survival factor, mediates tumor necrosis factor-alpha (TNF-alpha)-stimulated cardiac fibroblast proliferation but inhibits TNF-alpha-induced cardiomyocyte death." dans: The Journal of biological chemistry, Vol. 284, Issue 21, pp. 14414-27, (2009) (PubMed).
: "Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling." dans: Science (New York, N.Y.), Vol. 316, Issue 5827, pp. 1043-6, (2007) (PubMed).
: "Overexpression of WISP-1 down-regulated motility and invasion of lung cancer cells through inhibition of Rac activation." dans: The Journal of biological chemistry, Vol. 278, Issue 13, pp. 11465-70, (2003) (PubMed).
: "Human WISP1v, a member of the CCN family, is associated with invasive cholangiocarcinoma." dans: Hepatology (Baltimore, Md.), Vol. 37, Issue 5, pp. 1122-9, (2003) (PubMed).
: "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)." dans: The EMBO journal, Vol. 22, Issue 12, pp. 3084-94, (2003) (PubMed).
Synonymes et noms alternatifs relatifs à WISP1
WNT1 inducible signaling pathway protein 1 (WISP1), WNT1 inducible signaling pathway protein 1a (wisp1a), WNT1 inducible signaling pathway protein 1 (Wisp1), WNT1-inducible-signaling pathway protein 1-like (LOC100627044), WNT1 inducible signaling pathway protein 1b (wisp1b), AW146261, CCN4, Elm1, si:ch211-38f10.2, WISP-1, WISP1, WISP1c, WISP1i, WISP1tc, zgc:172276Protein level used designations for WISP1
- CCN family member 4
- WNT1 induced secreted protein 1
- WNT1-inducible-signaling pathway protein 1
- Wnt-1 inducible signaling pathway protein 1
- Wnt-1-induced secreted protein
- WNT1 inducible signaling pathway protein 1
- wisp1
- zWISP1-c19
- ELM-1
- WISP-1
- zWISP1-c16
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