WRAP53 Produits
(WD Repeat Containing, Antisense To TP53 (WRAP53))
Catégories
This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011].
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Catégories WRAP53 en vedette
WRAP53 Anticorps
High quality antibodies with extensive validation data.
WRAP53 Kits ELISA
Reliable ELISA kits for a wide range of species.
WRAP53 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
WRAP53 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (1)
- (4)
N° du produit
ABIN527367
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IF
Validations
- (1)
- (3)
N° du produit
ABIN527366
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB
Validations
- (1)
- (1)
N° du produit
ABIN527365
Quantité
50 μg
Fiche technique
Fiche technique
WRAP53 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Validations
N° du produit
ABIN1161126
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Validations
N° du produit
ABIN1161127
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Validations
N° du produit
ABIN1161128
Quantité
96 tests
Fiche technique
Fiche technique
WRAP53 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1325280
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1325282
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3096370
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits WRAP53
: "N-terminal residues of human dyskerin are required for interactions with telomerase RNA that prevent RNA degradation." dans: Nucleic acids research, Vol. 47, Issue 10, pp. 5368-5380, (2019) (PubMed).: "Clinical, cellular, and bioinformatic analyses reveal involvement of WRAP53 overexpression in carcinogenesis of lung adenocarcinoma." dans: Tumour biology, Vol. 39, Issue 3, pp. 1010428317694309, (2017) (PubMed).
: "Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies." dans: eLife, Vol. 5, (2016) (PubMed).
: "Dynamics of Human Telomerase Holoenzyme Assembly and Subunit Exchange across the Cell Cycle." dans: The Journal of biological chemistry, Vol. 290, Issue 35, pp. 21320-35, (2015) (PubMed).
: "Human regulator of telomere elongation helicase 1 (RTEL1) is required for the nuclear and cytoplasmic trafficking of pre-U2 RNA." dans: Nucleic acids research, Vol. 43, Issue 3, pp. 1834-47, (2015) (PubMed).
: "Downregulation of the cancer susceptibility protein WRAP53β in epithelial ovarian cancer leads to defective DNA repair and poor clinical outcome." dans: Cell death & disease, Vol. 6, pp. e1892, (2015) (PubMed).
: "The scaffold protein WRAP53? orchestrates the ubiquitin response critical for DNA double-strand break repair." dans: Genes & development, Vol. 28, Issue 24, pp. 2726-38, (2014) (PubMed).
: "TCAB1: a potential target for diagnosis and therapy of head and neck carcinomas." dans: Molecular cancer, Vol. 13, pp. 180, (2014) (PubMed).
: "Telomerase recruitment requires both TCAB1 and Cajal bodies independently." dans: Molecular and cellular biology, Vol. 32, Issue 13, pp. 2384-95, (2012) (PubMed).
: "WRAP53 promotes cancer cell survival and is a potential target for cancer therapy." dans: Cell death & disease, Vol. 2, pp. e114, (2011) (PubMed).
Synonymes et noms alternatifs relatifs à WRAP53
WD repeat containing antisense to TP53 (WRAP53), WD repeat containing, antisense to TP53 (Wrap53), WD repeat containing, antisense to Trp53 (Wrap53), BC021790, DKCB3, TCAB1, WDR79, Wdr79Protein level used designations for WRAP53
- WD repeat-containing protein 79
- WD40 protein Wrap53
- WD40 repeat-containing protein encoding RNA antisense to p53
- telomerase Cajal body protein 1
- WD repeat domain 79
- WD40 repeat-containing protein encoded by RNA antisense to p53
- WD repeat containing, antisense to TP53
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