Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

WRAP53 Produits

(WD Repeat Containing, Antisense To TP53 (WRAP53))

Catégories

This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011].

antibodies-online.com est synonyme de produits de recherche de haute qualité. Cherchez, trouvez et commandez des outils avec des données de validation étendues, des images, des références. Notre service clientèle scientifique est toujours à votre disposition si vous avez des questions sur la sélection ou l'application de nos produits.

Catégories WRAP53 en vedette

WRAP53 Anticorps

High quality antibodies with extensive validation data.

WRAP53 Kits ELISA

Reliable ELISA kits for a wide range of species.

WRAP53 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

WRAP53 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, IF
Validations
  • (1)
  • (4)
N° du produit ABIN527367
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, IF
Validations
  • (1)
  • (3)
N° du produit ABIN527366
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB
Validations
  • (1)
  • (1)
N° du produit ABIN527365
Quantité 50 μg
Fiche technique Fiche technique

WRAP53 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method
Validations
N° du produit ABIN1161126
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method
Validations
N° du produit ABIN1161127
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method
Validations
N° du produit ABIN1161128
Quantité 96 tests
Fiche technique Fiche technique

WRAP53 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1325280
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1325282
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3096370
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits WRAP53

MacNeil, Lambert-Lanteigne, Autexier: "N-terminal residues of human dyskerin are required for interactions with telomerase RNA that prevent RNA degradation." dans: Nucleic acids research, Vol. 47, Issue 10, pp. 5368-5380, (2019) (PubMed).

Yuan, Cao, Hu, Bao, Wang, Cao, Yuan, Lv, Hu: "Clinical, cellular, and bioinformatic analyses reveal involvement of WRAP53 overexpression in carcinogenesis of lung adenocarcinoma." dans: Tumour biology, Vol. 39, Issue 3, pp. 1010428317694309, (2017) (PubMed).

Vogan, Zhang, Youmans, Regalado, Johnson, Hockemeyer, Collins: "Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies." dans: eLife, Vol. 5, (2016) (PubMed).

Vogan, Collins: "Dynamics of Human Telomerase Holoenzyme Assembly and Subunit Exchange across the Cell Cycle." dans: The Journal of biological chemistry, Vol. 290, Issue 35, pp. 21320-35, (2015) (PubMed).

Schertzer, Jouravleva, Perderiset, Dingli, Loew, Le Guen, Bardoni, de Villartay, Revy, Londoño-Vallejo: "Human regulator of telomere elongation helicase 1 (RTEL1) is required for the nuclear and cytoplasmic trafficking of pre-U2 RNA." dans: Nucleic acids research, Vol. 43, Issue 3, pp. 1834-47, (2015) (PubMed).

Hedström, Pederiva, Farnebo, Nodin, Jirström, Brennan, Farnebo: "Downregulation of the cancer susceptibility protein WRAP53β in epithelial ovarian cancer leads to defective DNA repair and poor clinical outcome." dans: Cell death & disease, Vol. 6, pp. e1892, (2015) (PubMed).

Henriksson, Rassoolzadeh, Hedström, Coucoravas, Julner, Goldstein, Imreh, Zhivotovsky, Kastan, Helleday, Farnebo: "The scaffold protein WRAP53? orchestrates the ubiquitin response critical for DNA double-strand break repair." dans: Genes & development, Vol. 28, Issue 24, pp. 2726-38, (2014) (PubMed).

Sun, Luo, Gou, Hu, Wang, Li, Xiang, Zhang, Kong, Zhang, Yang, Li, Xiao, Li, Chen: "TCAB1: a potential target for diagnosis and therapy of head and neck carcinomas." dans: Molecular cancer, Vol. 13, pp. 180, (2014) (PubMed).

Stern, Zyner, Pickett, Cohen, Bryan: "Telomerase recruitment requires both TCAB1 and Cajal bodies independently." dans: Molecular and cellular biology, Vol. 32, Issue 13, pp. 2384-95, (2012) (PubMed).

Mahmoudi, Henriksson, Farnebo, Roberg, Farnebo: "WRAP53 promotes cancer cell survival and is a potential target for cancer therapy." dans: Cell death & disease, Vol. 2, pp. e114, (2011) (PubMed).

Synonymes et noms alternatifs relatifs à WRAP53

WD repeat containing antisense to TP53 (WRAP53), WD repeat containing, antisense to TP53 (Wrap53), WD repeat containing, antisense to Trp53 (Wrap53), BC021790, DKCB3, TCAB1, WDR79, Wdr79

Protein level used designations for WRAP53

  • WD repeat-containing protein 79
  • WD40 protein Wrap53
  • WD40 repeat-containing protein encoding RNA antisense to p53
  • telomerase Cajal body protein 1
  • WD repeat domain 79
  • WD40 repeat-containing protein encoded by RNA antisense to p53
  • WD repeat containing, antisense to TP53
Vous êtes ici:
Support technique