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YARS Produits

(Tyrosyl-tRNA Synthetase (Yars))

Catégories

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008].

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Catégories YARS en vedette

YARS Anticorps

High quality antibodies with extensive validation data.

YARS Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

YARS recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (7)
N° du produit ABIN7443434
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (5)
N° du produit ABIN7173996
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA
Validations
  • (2)
  • (4)
N° du produit ABIN563694
Quantité 50 μg
Fiche technique Fiche technique

YARS recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7125569
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1325501
Quantité 25 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN2132594
Quantité 50 μg
Fiche technique Fiche technique

Dernières publications sur nos produits YARS

Zhang, Zhai, Tang, Cheng, Li, Wang, Zhu: "Quantitative proteome-based systematic identification of SIRT7 substrates." dans: Proteomics, Vol. 17, Issue 13-14, (2017) (PubMed).

Wei, Xu, Liu, Lo, Ye, Lau, Wang, Zhou, Nangle, Yang, Zhang, Schimmel: "Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase." dans: Nucleic acids research, Vol. 44, Issue 3, pp. 1247-55, (2016) (PubMed).

Niehues, Bussmann, Steffes, Erdmann, Köhrer, Sun, Wagner, Schäfer, Wang, Koerdt, Stum, RajBhandary, Thomas, Aberle, Burgess, Yang, Dieterich, Storkebaum: "Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases." dans: Nature communications, Vol. 6, pp. 7520, (2015) (PubMed).

Storkebaum, Leitão-Gonçalves, Godenschwege, Nangle, Mejia, Bosmans, Ooms, Jacobs, Van Dijck, Yang, Schimmel, Norga, Timmerman, Callaerts, Jordanova: "Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 28, pp. 11782-7, (2009) (PubMed).

Yang, Kapoor, Otero, Slike, Tsuruta, Frausto, Bates, Ewalt, Cheresh, Schimmel: "Gain-of-function mutational activation of human tRNA synthetase procytokine." dans: Chemistry & biology, Vol. 14, Issue 12, pp. 1323-33, (2007) (PubMed).

Jordanova, Irobi, Thomas, Van Dijck, Meerschaert, Dewil, Dierick, Jacobs, De Vriendt, Guergueltcheva, Rao, Tournev, Gondim, DHooghe, Van Gerwen, Callaerts, Van Den Bosch, Timmermans, Robberecht et al.: "Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. ..." dans: Nature genetics, Vol. 38, Issue 2, pp. 197-202, (2006) (PubMed).

Bonnefond, Fender, Rudinger-Thirion, Giegé, Florentz, Sissler: "Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS." dans: Biochemistry, Vol. 44, Issue 12, pp. 4805-16, (2005) (PubMed).

Synonymes et noms alternatifs relatifs à YARS

tyrosyl-tRNA synthetase (YARS), tyrosyl-tRNA synthetase (Yars), tyrosyl-tRNA synthetase (yars), tyrosyl-tRNA synthetase L homeolog (yars.L), tyrosyl-tRNA synthetase, putative (MAL8P1.125), tyrosine--tRNA ligase (MEFER_RS04475), Tyrosyl-tRNA synthetase (TyrRS), tyrosine--tRNA ligase, cytoplasmic (LOC413909), tyrosine--tRNA ligase, cytoplasmic (LOC100163888), tyrosyl-tRNA synthetase (LOC100282315), AL024047, anon-EST:Posey261, AU018965, cb204, CG4561, CMTDIC, cmtdic, Dmel\\CG4561, dYARS, GB10789, TYRRS, tyrrs, TyrRS, wu:fk52b08, YARS, YRS, yrs, YTS, yts

Protein level used designations for YARS

  • tyrosine tRNA ligase 1, cytoplasmic
  • tyrosine--tRNA ligase, cytoplasmic
  • tyrosyl--tRNA ligase
  • tyrosyl-tRNA synthetase, cytoplasmic
  • Tyrosyl-tRNA synthetase, cytoplasmic
  • tyrRS
  • tyrosyl-tRNA synthetase
  • Aats-tyr-PA
  • CG4561-PA
  • ACYPI004940
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