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ZAK Produits

(Mitogen-Activated Protein Kinase Kinase Kinase MLT (ZAK))
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].

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Catégories ZAK en vedette

ZAK Anticorps

High quality antibodies with extensive validation data.

ZAK Kits ELISA

Reliable ELISA kits for a wide range of species.

ZAK Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

ZAK recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, IF, IHC (p)
Validations
  • (3)
  • (5)
N° du produit ABIN565679
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC, IF
Validations
  • (4)
N° du produit ABIN6150360
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC (p)
Validations
  • (1)
  • (2)
N° du produit ABIN392643
Quantité 400 μL
Fiche technique Fiche technique

ZAK recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Mouse
Analytical Method
Validations
N° du produit ABIN1142997
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
N° du produit ABIN5595441
Quantité 96 tests
Fiche technique Fiche technique

ZAK recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (2)
N° du produit ABIN1325564
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1325566
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Insect Cells
Validations
N° du produit ABIN5509200
Quantité 10 μg
Fiche technique Fiche technique

Dernières publications sur nos produits ZAK

Pescatore, Esposito, Draber, Walczak, Ursini: "NEMO regulates a cell death switch in TNF signaling by inhibiting recruitment of RIPK3 to the cell death-inducing complex II." dans: Cell death & disease, Vol. 7, Issue 8, pp. e2346, (2017) (PubMed).

Nyati, Chator, Schinske, Gregg, Ross, Rehemtulla: "A Requirement for ZAK Kinase Activity in Canonical TGF-β Signaling." dans: Translational oncology, Vol. 9, Issue 6, pp. 473-481, (2016) (PubMed).

Liu, McCleland, Stawiski, Gnad, Mayba, Haverty, Durinck, Chen, Klijn, Jhunjhunwala, Lawrence, Liu, Wan, Chopra, Yaylaoglu, Yuan, Ha, Gilbert, Reeder, Pau, Stinson, Stern, Manning, Wu, Neve et al.: "Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer. ..." dans: Nature communications, Vol. 5, pp. 3830, (2014) (PubMed).

Pérez López, Cariolato, Maric, Gillet, Abriel, Diviani: "A-kinase anchoring protein Lbc coordinates a p38 activating signaling complex controlling compensatory cardiac hypertrophy." dans: Molecular and cellular biology, Vol. 33, Issue 15, pp. 2903-17, (2013) (PubMed).

Cariolato, Cavin, Diviani: "A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in ?1-adrenergic receptor-induced p38 activation." dans: The Journal of biological chemistry, Vol. 286, Issue 10, pp. 7925-37, (2011) (PubMed).

Cantrell: "Phosphoinositide 3-kinase signalling pathways." dans: Journal of cell science, Vol. 114, Issue Pt 8, pp. 1439-45, (2001) (PubMed).

Blume-Jensen, Hunter: "Oncogenic kinase signalling." dans: Nature, Vol. 411, Issue 6835, pp. 355-65, (2001) (PubMed).

Jhiang: "The RET proto-oncogene in human cancers." dans: Oncogene, Vol. 19, Issue 49, pp. 5590-7, (2000) (PubMed).

Synonymes et noms alternatifs relatifs à ZAK

mitogen-activated protein kinase kinase kinase 20 (Map3k20), mitogen-activated protein kinase kinase kinase 20 (MAP3K20), AV006891, AZK, B230120H23Rik, MLK7, mlklak, MLT, MLTK, MLTKalpha, MLTKbeta, MRK, pk, RGD1561394

Protein level used designations for ZAK

  • mitogen-activated protein kinase kinase kinase MLT
  • HCCS-4
  • MLK-like mitogen-activated protein triple kinase
  • human cervical cancer suppressor gene 4 protein
  • mixed lineage kinase 7
  • mixed lineage kinase with a leucine zipper and a sterile alpha motif
  • mixed lineage kinase-related kinase MRK-beta
  • MLK-related kinase
  • MRK
  • leucine zipper- and sterile alpha motif kinase ZAK
  • mixed lineage kinase-related kinase
  • sterile alpha motif- and leucine zipper-containing kinase AZK
  • sterile-alpha motif and leucine zipper containing kinase AZK
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