ZAP70 Produits
(zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70))
Catégories
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Catégories ZAP70 en vedette
ZAP70 Anticorps
High quality antibodies with extensive validation data.
ZAP70 Kits ELISA
Reliable ELISA kits for a wide range of species.
ZAP70 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
ZAP70 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, FACS, ICC
Validations
- (1)
- (6)
N° du produit
ABIN125756
Quantité
0.1 mg
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA, IF, ICC
Validations
- (8)
N° du produit
ABIN6255884
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, FACS
Validations
- (5)
N° du produit
ABIN7193547
Quantité
100 μL
Fiche technique
Fiche technique
ZAP70 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6971215
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
N° du produit
ABIN4886351
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
N° du produit
ABIN1380734
Quantité
2 x 96 tests
Fiche technique
Fiche technique
ZAP70 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (2)
N° du produit
ABIN1325570
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1325572
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Insect Cells
Validations
N° du produit
ABIN5509201
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits ZAP70
: "Fibulin-3 may improve vascular health through inhibition of MMP-2/9 and oxidative stress in spontaneously hypertensive rats." dans: Molecular medicine reports, Vol. 13, Issue 5, pp. 3805-12, (2017) (PubMed).: "Hypertensive vascular remodeling was inhibited by Xuezhikang through the regulation of Fibulin-3 and MMPs in spontaneously hypertensive rats." dans: International journal of clinical and experimental medicine, Vol. 8, Issue 2, pp. 2118-27, (2015) (PubMed).
: "PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis." dans: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 19617-29, (2011) (PubMed).
: "ZAP-70 enhances B-cell-receptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells." dans: Blood, Vol. 109, Issue 5, pp. 2032-9, (2007) (PubMed).
: "CTLA-4 disrupts ZAP70 microcluster formation with reduced T cell/APC dwell times and calcium mobilization." dans: European journal of immunology, Vol. 38, Issue 1, pp. 40-7, (2007) (PubMed).
: "T cell activation-induced CrkII binding to the Zap70 protein tyrosine kinase is mediated by Lck-dependent phosphorylation of Zap70 tyrosine 315." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 12, pp. 8123-32, (2005) (PubMed).
: "Immunohistochemical analysis of ZAP-70 expression in B-cell lymphoid neoplasms." dans: The Journal of pathology, Vol. 205, Issue 4, pp. 507-13, (2005) (PubMed).
: "[Everything you ever wanted to know about ZAP-70]." dans: Médecine sciences : M/S, Vol. 21, Issue 2, pp. 150-5, (2005) (PubMed).
: "In vivo correction of ZAP-70 immunodeficiency by intrathymic gene transfer." dans: The Journal of clinical investigation, Vol. 115, Issue 8, pp. 2287-95, (2005) (PubMed).
: "Evidence for the involvement of tyrosine kinase ZAP 70 in nuclear retinoid receptor-dependent transactivation in T lymphocytes." dans: The Journal of biological chemistry, Vol. 280, Issue 40, pp. 34152-8, (2005) (PubMed).
Synonymes et noms alternatifs relatifs à ZAP70
zeta chain of T-cell receptor associated protein kinase 70 (ZAP70), putative tyrosine-protein kinase zap-70 (Smp_149470), zeta-chain (TCR) associated protein kinase (Zap70), zeta chain of T cell receptor associated protein kinase 70 (Zap70), zeta-chain (TCR) associated protein kinase 70kDa (ZAP70), zeta chain of T cell receptor associated protein kinase 70kDa L homeolog (zap70.L), zeta chain of T cell receptor associated protein kinase 70kDa (zap70), zeta chain of T cell receptor associated protein kinase 70 (ZAP70), tyrosine-protein kinase ZAP-70 (LOC707555), tyrosine-protein kinase ZAP-70 (ZAP70), tyrosine-protein kinase ZAP-70 (LOC100342021), tyrosine-protein kinase ZAP-70 (LOC100390922), tyrosine-protein kinase ZAP-70 (LOC100542877), zeta-chain (TCR) associated protein kinase 70kDa (Zap70), zeta-chain (TCR) associated protein kinase (zap70), 70kDa, AI327364, MGC80670, MGC88962, mrtle, mur, SRK, Srk, STCD, STD, TZK, ZAP-70, zap70, ZAP70, zgc:110383Protein level used designations for ZAP70
- 70 kDa zeta-associated protein
- 70 kDa zeta-chain associated protein
- syk-related tyrosine kinase
- tyrosine-protein kinase ZAP-70
- zeta-chain associated protein kinase, 70kD
- tyrosine-protein kinase zap-70
- syk-related protein tyrosine kinase
- zeta-chain (TCR) associated protein kinase 70kDa
- zeta-chain associated protein kinase 70kDa
- tyrosine-protein kinase ZAP-70-like
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